Universität zu Köln

Fiess, Achim, Christian, Luka, Janz, Johannes, Koelb-Keerl, Ruth, Knuf, Markus, Kirchhof, Bernd, Muether, Philipp S. and Bauer, Jacqueline (2017). Functional analysis and associated factors of the peripapillary retinal nerve fibre layer in former preterm and full-term infants. Br. J. Ophthalmol., 101 (10). S. 1405 - 1412. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2079

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Abstract

Purpose The aim of the study was to investigate peripapillary retinal nerve fibre layer thickness (RNFLT) in former preterm infants and full-term neonates using spectral-domain optical coherence tomography (SD-OCT). Methods The prospective, controlled, cross-sectional, hospital-based study in a tertiary centre with maximum care examined 503 infants with a former gestational age (GA) of >= 37 and <= 32 weeks now aged between 4 and 10 years. In total, we analysed 432 participants with successful circular peripapillary RNFLT OCT measurements. Main outcome measures were RNFLT correlations to GA, birth weight, occurrence of retinopathy of prematurity (ROP), perinatal adverse events as well as functional correlation. Results Global RNFLT was thinner in infants with GA <= 28 weeks compared with infants with GA between 29 and 32 weeks (p=0.024), and to full-term neonates (p=0.007) independent of the occurrence of ROP. Multivariable analysis revealed that RNFLT was positively associated with higher birth weight and GA. Furthermore, a decrease of RNFLT was related to reduced visual function in all peripapillary sectors. Conclusions The main factors for retinal nerve fibre layer thinning are low birth weight and low GA. In addition, decreased RNFLT was associated with reduced visual function. This demonstrates that preterm infants are at high risk for peripapillary RNFL damage associated with reduced visual function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fiess, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Christian, Luka UNSPECIFIED UNSPECIFIED UNSPECIFIED Janz, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Koelb-Keerl, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Knuf, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Muether, Philipp S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Jacqueline UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-216287
DOI:	10.1136/bjophthalmol-2016-309622
Journal or Publication Title:	Br. J. Ophthalmol.
Volume:	101
Number:	10
Page Range:	S. 1405 - 1412
Date:	2017
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-2079
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; GESTATIONAL-AGE; CHILDREN BORN; THICKNESS; PREMATURITY; RETINOPATHY; OCT; INJURY Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21628