Universität zu Köln

Mantziaris, Charalampos ORCID: 0000-0003-2280-1733, Bockemuehl, Till, Holmes, Philip, Borgmann, Anke, Daun, Silvia ORCID: 0000-0001-7342-1015 and Bueschges, Ansgar (2017). Intra- and intersegmental influences among central pattern generating networks in the walking system of the stick insect. J. Neurophysiol., 118 (4). S. 2296 - 2311. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1598

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Abstract

To efficiently move around, animals need to coordinate their limbs. Proper, context-dependent coupling among the neural networks underlying leg movement is necessary for generating intersegmental coordination. In the slow-walking stick insect, local sensory information is very important for shaping coordination. However, central coupling mechanisms among segmental central pattern generators (CPGs) may also contribute to this. Here, we analyzed the interactions between contralateral networks that drive the depressor trochanteris muscle of the legs in both isolated and interconnected deafferented thoracic ganglia of the stick insect on application of pilocarpine, a muscarinic acetylcholine receptor agonist. Our results show that depressor CPG activity is only weakly coupled between all segments. Intrasegmental phase relationships differ between the three isolated ganglia, and they are modified and stabilized when ganglia are interconnected. However, the coordination patterns that emerge do not resemble those observed during walking. Our findings are in line with recent studies and highlight the influence of sensory input on coordination in slowly walking insects. Finally, as a direct interaction between depressor CPG networks and contralateral motoneurons could not be observed, we hypothesize that coupling is based on interactions at the level of CPG interneurons. NEW & NOTEWORTHY Maintaining functional interleg coordination is vitally important as animals locomote through changing environments. The relative importance of central mechanisms vs. sensory feedback in this process is not well understood. We analyzed coordination among the neural networks generating leg movements in stick insect preparations lacking phasic sensory feedback. Under these conditions, the networks governing different legs were only weakly coupled. In stick insect, central connections alone are thus insufficient to produce the leg coordination observed behaviorally.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mantziaris, Charalampos UNSPECIFIED orcid.org/0000-0003-2280-1733 UNSPECIFIED Bockemuehl, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED Holmes, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgmann, Anke UNSPECIFIED UNSPECIFIED UNSPECIFIED Daun, Silvia UNSPECIFIED orcid.org/0000-0001-7342-1015 UNSPECIFIED Bueschges, Ansgar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-216772
DOI:	10.1152/jn.00321.2017
Journal or Publication Title:	J. Neurophysiol.
Volume:	118
Number:	4
Page Range:	S. 2296 - 2311
Date:	2017
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	BETHESDA
ISSN:	1522-1598
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTER-LEG COORDINATION; CARAUSIUS-MOROSUS; THORACIC GANGLIA; COMMISSURAL INTERNEURONS; RHYTHMIC PATTERNS; NEURONAL NETWORKS; SENSORY SIGNALS; SYNAPTIC DRIVE; MOTOR OUTPUT; NERVE CORD Multiple languages Neurosciences; Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21677