Universität zu Köln

Revankar, Sanjay G., Baddley, John W., Chen, Sharon C. -A., Kauffman, Carol A., Slavin, Monica, Vazquez, Jose A., Seas, Carlos, Morris, Michele I., Nguyen, M. Hong, Shoham, Shmuel, Thompson, George R., III, Alexander, Barbara D., Simkins, Jacques, Ostrosky-Zeichner, Luis, Mullane, Kathleen, Alangaden, George, Andes, David R., Cornely, Oliver A., Wahlers, Kerstin, Lockhart, Shawn R. and Pappas, Peter G. (2017). A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases. Open Forum Infect. Dis., 4 (4). CARY: OXFORD UNIV PRESS INC. ISSN 2328-8957

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Abstract

Background. Phaeohyphomycosis is infection caused by dematiaceous, or darkly pigmented, fungi. The spectrum of disease is broad, and optimal therapy remains poorly defined. The Mycoses Study Group established an international case registry of patients with proven/probable phaeohyphomycosis with the goal of improving the recognition and management of these infections. Methods. Patients from 18 sites in 3 countries were enrolled from 2009-2015. Cases were categorized as local superficial, local deep (pulmonary, sinus, osteoarticular infections), and disseminated infections. End points were clinical response (partial and complete) and all-cause mortality at 30 days and end of follow-up. Results. Of 99 patients, 32 had local superficial infection, 41 had local deep infection, and 26 had disseminated infection. The most common risk factors were corticosteroids, solid organ transplantation, malignancy, and diabetes. Cultures were positive in 98% of cases. All-cause mortality was 16% at 30 days and 33% at end of follow-up, and 18 of 26 (69%) with dissemination died. Itraconazole was most commonly used for local infections, and voriconazole was used for more severe infections, often in combination with terbinafine or amphotericin B. Conclusions. Phaeohyphomycosis is an increasingly recognized infection. Culture remains the most frequently used diagnostic method. Triazoles are currently the drugs of choice, often combined with other agents. Further studies are needed to develop optimal therapies for disseminated infections.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Revankar, Sanjay G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baddley, John W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Sharon C. -A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kauffman, Carol A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Slavin, Monica UNSPECIFIED UNSPECIFIED UNSPECIFIED Vazquez, Jose A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seas, Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Morris, Michele I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nguyen, M. Hong UNSPECIFIED UNSPECIFIED UNSPECIFIED Shoham, Shmuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Thompson, George R., III UNSPECIFIED UNSPECIFIED UNSPECIFIED Alexander, Barbara D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simkins, Jacques UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostrosky-Zeichner, Luis UNSPECIFIED UNSPECIFIED UNSPECIFIED Mullane, Kathleen UNSPECIFIED UNSPECIFIED UNSPECIFIED Alangaden, George UNSPECIFIED UNSPECIFIED UNSPECIFIED Andes, David R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Lockhart, Shawn R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pappas, Peter G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-218104
DOI:	10.1093/ofid/ofx200
Journal or Publication Title:	Open Forum Infect. Dis.
Volume:	4
Number:	4
Date:	2017
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	2328-8957
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVASIVE FUNGAL-INFECTIONS; DESORPTION IONIZATION-TIME; FLIGHT MASS-SPECTROMETRY; MELANIZED FUNGI; IDENTIFICATION; MOLDS; MANAGEMENT; DIAGNOSIS; VIRULENCE; THERAPY Multiple languages Immunology; Infectious Diseases; Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21810