Universität zu Köln

Drake, Gabby J., Nuttall, Tim, Lopez, Javier, Magnone, William, Leclerc, Antoine, Potier, Romain, Lecu, Alexis, Guezenec, Maelle, Kolter, Lydia, Nicolau, Amelie, Lemberger, Karin, Pin, Didier and Cosgrove, Sallie B. (2017). TREATMENT SUCCESS IN THREE ANDEAN BEARS (TREMARCTOS ORNATUS) WITH ALOPECIA SYNDROME USING OCLACITINIB MALEATE (APOQUEL (R)). J. Zoo Wildl. Med., 48 (3). S. 818 - 829. YULEE: AMER ASSOC ZOO VETERINARIANS. ISSN 1937-2825

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Abstract

Andean bear (Tremarctos ornatus) alopecia syndrome (ABAS) commonly affects captive bears, particularly sexually mature females. ABAS is characterized by bilaterally symmetrical predominantly flank alopecia with or without profound pruritus and secondary bacterial and Malassezia infections. There is no effective treatment and severely affected bears have been euthanized. This paper describes the successful management of ABAS in three female Andean bears. Skin biopsies and cytology revealed a mixed dermal inflammatory infiltrate, alopecia, hyperkeratosis, and Malassezia dermatitis. Allergen specific serology was positive for environmental allergens in one case. Hematology, serum biochemistry, and thyroid and adrenal function were normal in all cases. There was no consistent response to novel diet trials, antifungals, antihistamines, allergen specific immunotherapy, or topical antimicrobials. There was a partial response to ciclosporin (Atopicat cat, Novartis Animal Health; 5 mg/kg po, sid) in one case and oral glucocorticoids in all cases (dexamethasone sodium phosphate, [Colvasone 0.2%, Norbrook], 0.15 mg/kg po, sid or prednisolone [Deltacortene, Bruno Farmaceutici, and Megasolone 20, Coophavet], 0.3-1.2 mg/kg po, sid), but treatment was withdrawn following adverse effects. Treatment with oclacitinib maleate (Apoquelt, Zoetis; 0.46-0.5 mg/kg po, bid) resulted in rapid and complete resolution of the pruritus with subsequent improvement in demeanor and fur regrowth. After 5 mo, the bears were almost fully furred and off all other medication. Treatment was tapered to the lowest dose that prevented relapse of the pruritus (0.23-0.4 mg/kg po, sid). No adverse effects have been noted. ABAS is usually an intractable condition, and, to our knowledge, oclacitinib is the first treatment shown to result in sustained clinical improvement. Further studies on the etiology of ABAS, and on efficacy and long-term safety of oclacitinib are needed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Drake, Gabby J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuttall, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Lopez, Javier UNSPECIFIED UNSPECIFIED UNSPECIFIED Magnone, William UNSPECIFIED UNSPECIFIED UNSPECIFIED Leclerc, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Potier, Romain UNSPECIFIED UNSPECIFIED UNSPECIFIED Lecu, Alexis UNSPECIFIED UNSPECIFIED UNSPECIFIED Guezenec, Maelle UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolter, Lydia UNSPECIFIED UNSPECIFIED UNSPECIFIED Nicolau, Amelie UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemberger, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Pin, Didier UNSPECIFIED UNSPECIFIED UNSPECIFIED Cosgrove, Sallie B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-218691
DOI:	10.1638/2016-0239.1
Journal or Publication Title:	J. Zoo Wildl. Med.
Volume:	48
Number:	3
Page Range:	S. 818 - 829
Date:	2017
Publisher:	AMER ASSOC ZOO VETERINARIANS
Place of Publication:	YULEE
ISSN:	1937-2825
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANINE ATOPIC-DERMATITIS; EFFICACY; DOGS; INTERLEUKIN-31; TOFACITINIB; DIAGNOSIS; PRURITUS; THERAPY; SAFETY Multiple languages Veterinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21869