Universität zu Köln

Mueller, Stephan, Preische, Oliver, Goepfert, Jens C., Yanez, Viviana A. Carcamo, Joos, Thomas O., Boecker, Henning, Duezel, Emrah, Falkai, Peter ORCID: 0000-0003-2873-8667, Priller, Josef ORCID: 0000-0001-7596-0979, Buerger, Katharina, Catak, Cihan, Janowitz, Daniel, Heneka, Michael T., Brosseron, Frederic, Nestor, Peter ORCID: 0000-0002-5860-5921, Peters, Oliver, Menne, Felix, Schipke, Carola G., Schneider, Anja ORCID: 0000-0001-9540-8700, Spottke, Annika, Fliessbach, Klaus, Kilimann, Ingo, Teipel, Stefan, Wagner, Michael ORCID: 0000-0003-2589-6440, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Jessen, Frank and Laske, Christoph (2017). Tau plasma levels in subjective cognitive decline: Results from the DELCODE study. Sci Rep, 7. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Previous studies have demonstrated increased tau plasma levels in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) due to AD. Much less is known whether increased tau plasma levels can already be detected in the pre-MCI stage of subjective cognitive decline (SCD). In the present study we measured tau plasma levels in 111 SCD patients and 134 age- and gender-matched cognitively healthy controls participating in the DZNE (German Center for Neurodegenerative Diseases) longitudinal study on cognition and dementia (DELCODE). Tau plasma levels were measured using ultra-sensitive, single-molecule array (Simoa) technology. We found no significant different tau plasma levels in SCD (3.4 pg/ml) compared with healthy controls (3.6 pg/ml) after controlling for age, gender, and education (p = 0.137). In addition, tau plasma levels did not correlate with A beta 42 (r = 0.073; p = 0.634), tau (r = -0.179; p = 0.240), and p-tau181 (r = -0.208; p = 0.171) cerebrospinal fluid (CSF) levels in a subgroup of 45 SCD patients with available CSF. In conclusion, plasma tau is not increased in SCD patients. In addition, the lack of correlation between tau in plasma and CSF in the examined cohort suggests that tau levels are affected by different factors in both biofluids.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Preische, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Goepfert, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yanez, Viviana A. Carcamo UNSPECIFIED UNSPECIFIED UNSPECIFIED Joos, Thomas O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boecker, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Duezel, Emrah UNSPECIFIED UNSPECIFIED UNSPECIFIED Falkai, Peter UNSPECIFIED orcid.org/0000-0003-2873-8667 UNSPECIFIED Priller, Josef UNSPECIFIED orcid.org/0000-0001-7596-0979 UNSPECIFIED Buerger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Catak, Cihan UNSPECIFIED UNSPECIFIED UNSPECIFIED Janowitz, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneka, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brosseron, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestor, Peter UNSPECIFIED orcid.org/0000-0002-5860-5921 UNSPECIFIED Peters, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Menne, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Schipke, Carola G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Anja UNSPECIFIED orcid.org/0000-0001-9540-8700 UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kilimann, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Teipel, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Wiltfang, Jens UNSPECIFIED orcid.org/0000-0003-1492-5330 UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Laske, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-221461
DOI:	10.1038/s41598-017-08779-0
Journal or Publication Title:	Sci Rep
Volume:	7
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LINKED-IMMUNOSORBENT-ASSAY; EARLY ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; MEMORY IMPAIRMENT; DEMENTIA; PROTEINS; RISK; MCI; CSF Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22146