Universität zu Köln

Gesing, Julia, Scheuermann, Kathrin, Wagner, Isabel Viola, Loeffler, Dennis, Friebe, Daniela, Kiess, Wieland, Schuster, Volker and Koerner, Antje (2017). NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children. PLoS One, 12 (8). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood. It is, however, not clear whether this association reflects a chronic elevation or acute inflammatory response. We analyzed NAMPT concentrations in distinct states of inflammation in 102 children and found consistently significantly increased NAMPT levels in subjects with acute infections. NAMPT concentrations in children with stable chronic inflammatory diseases were not significantly different, whereas in patients with acute relapse of chronic disease NAMPT was significantly higher than in children in remission or healthy controls. In states of low-grade inflammation (children with atopic disease or obesity) we did not detect alterations in NAMPT serum levels. NAMPT correlated positively with inflammatory markers such as CRP. The most predictive factor for NAMPT serum concentrations was leucocyte count and therein the neutrophil count. Furthermore, systemic circulating NAMPT levels were closely associated with NAMPT release from corresponding cultured PBMCs. In conclusion, NAMPT is selectively increased in states of acute but not chronic inflammation in children. The close relationship between systemic circulating NAMPT with leucocyte counts and release indicate that leucocytes most probably are the source of inflammation related NAMPT levels.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gesing, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheuermann, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Isabel Viola UNSPECIFIED UNSPECIFIED UNSPECIFIED Loeffler, Dennis UNSPECIFIED UNSPECIFIED UNSPECIFIED Friebe, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiess, Wieland UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuster, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Koerner, Antje UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-221492
DOI:	10.1371/journal.pone.0183027
Journal or Publication Title:	PLoS One
Volume:	12
Number:	8
Date:	2017
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLONY-ENHANCING FACTOR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; VISFATIN; ADIPOCYTOKINE; ARTHRITIS; PROTEIN Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22149