Universität zu Köln

McCarthy, Matthew W., Kontoyiannis, Dimitrios P., Cornely, Oliver A., Perfect, John R. and Walsh, Thomas J. (2017). Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi. J. Infect. Dis., 216. S. S474 - 10. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6613

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Abstract

The emergence of drug-resistant fungi poses a major threat to human health. Despite advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections continue to cause significant morbidity and mortality in patients with compromised immunity, underscoring the urgent need for new antifungal agents. In this article, we review the challenges associated with identifying broad-spectrum antifungal drugs and highlight novel targets that could enhance the armamentarium of agents available to treat drug-resistant invasive fungal infections.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code McCarthy, Matthew W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kontoyiannis, Dimitrios P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Perfect, John R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walsh, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-221767
DOI:	10.1093/infdis/jix130
Journal or Publication Title:	J. Infect. Dis.
Volume:	216
Page Range:	S. S474 - 10
Date:	2017
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1537-6613
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-VITRO ACTIVITY; BROAD-SPECTRUM ANTIFUNGAL; COMPARATIVE GENOMIC ANALYSIS; CELECOXIB DERIVATIVE AR-12; PROTEIN-KINASE PATHWAY; CELL-WALL; ASPERGILLUS-FUMIGATUS; MURINE MODEL; PULMONARY COCCIDIOIDOMYCOSIS; GLYOXYLATE CYCLE Multiple languages Immunology; Infectious Diseases; Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22176