Universität zu Köln

Franzmeier, Nicolai ORCID: 0000-0001-9736-2283, Goettler, Jens, Grimmer, Timo, Drzezga, Alexander, Araque-Caballero, Miguel A., Simon-Vermot, Lee, Taylor, Alexander N. W., Buerger, Katharina, Catak, Cihan, Janowitz, Daniel, Mueller, Claudia, Duering, Marco, Sorg, Christian and Ewers, Michael (2017). Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment. Front. Aging Neurosci., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

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Abstract

Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer's disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFC-connectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the frontoparietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anti-correlation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFC-connectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Franzmeier, Nicolai UNSPECIFIED orcid.org/0000-0001-9736-2283 UNSPECIFIED Goettler, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Araque-Caballero, Miguel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon-Vermot, Lee UNSPECIFIED UNSPECIFIED UNSPECIFIED Taylor, Alexander N. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buerger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Catak, Cihan UNSPECIFIED UNSPECIFIED UNSPECIFIED Janowitz, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Duering, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ewers, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-221922
DOI:	10.3389/fnagi.2017.00264
Journal or Publication Title:	Front. Aging Neurosci.
Volume:	9
Date:	2017
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1663-4365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS-DISEASE; FUNCTIONAL CONNECTIVITY; BRAIN ACTIVITY; OLDER-ADULTS; MEMORY; HIPPOCAMPAL; CONNECTOMICS; REGISTRATION; ORGANIZATION; ASSOCIATION Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22192