Universität zu Köln

Mcguinness, Myra B., Le, Jerome, Mitchell, Paul, Gopinath, Bamini ORCID: 0000-0003-3573-359X, Cerin, Ester ORCID: 0000-0002-7599-165X, Saksens, Nicole T. M., Schick, Tina, Hoyng, Carel B., Guymer, Robyn H. and Finger, Robert P. (2017). Physical Activity and Age-related Macular Degeneration: A Systematic Literature Review and Meta-analysis. Am. J. Ophthalmol., 180. S. 29 - 39. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-1891

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Abstract

PURPOSE: To better understand the association, in a white population, of physical activity and age-related macular degeneration (AMD)-the main cause of irreversible severe vision loss in developed countries-given the suggestion that a healthy lifestyle may assist in delaying the onset and progression of AMD. DESIGN: Systematic review and meta-analysis. METHODS: Medline, EMBASE, and Google Scholar were systematically searched for studies up to May 2015. Reference lists of published articles were hand searched and study authors were contacted to provide additional data. Those in the lowest category of activity in each study were compared with all other participants to assess the association between physical activity and both early and late AMD using random-effects meta-analysis. RESULTS: Nine studies (subject age range 30-97 years) were included in the meta-analysis. Physical activity was found to have a protective association with both early AMD (8 studies, n = 38 112, odds ratio (OR) 0.92, 95% confidence interval [CI] 0.86-0.98) and late AMD (7 studies, n = 28 854, OR 0.59, 95% CI 0.49-0.72). CONCLUSIONS: Physical activity is associated with lower odds of early and late AMD in white populations. These findings have important implications, reinforcing the public health message of staying active throughout life. However, further longitudinal studies are required to confirm and further characterize a protective effect of physical activity on the onset and/or progression of AMD. (C) 2017 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mcguinness, Myra B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Le, Jerome UNSPECIFIED UNSPECIFIED UNSPECIFIED Mitchell, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Gopinath, Bamini UNSPECIFIED orcid.org/0000-0003-3573-359X UNSPECIFIED Cerin, Ester UNSPECIFIED orcid.org/0000-0002-7599-165X UNSPECIFIED Saksens, Nicole T. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schick, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guymer, Robyn H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Finger, Robert P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-223105
DOI:	10.1016/j.ajo.2017.05.016
Journal or Publication Title:	Am. J. Ophthalmol.
Volume:	180
Page Range:	S. 29 - 39
Date:	2017
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-1891
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BEAVER DAM EYE; 7-YEAR FOLLOW-UP; RISK-FACTORS; GRADING SYSTEM; PREVALENCE; ASSOCIATION; MACULOPATHY; HEALTH; COHORT; MORTALITY Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22310