Universität zu Köln

Janssen, Marcus L. F., Temel, Yasin, Delaville, Claire, Zwartjes, Daphne G. M., Heida, Tjitske, De Deurwaerdere, Philippe ORCID: 0000-0002-1226-3516, Visser-Vandewalle, Veerle and Benazzouz, Abdelhamid (2017). Cortico-subthalamic inputs from the motor, limbic, and associative areas in normal and dopamine-depleted rats are not fully segregated. Brain Struct. Funct., 222 (6). S. 2473 - 2486. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-2661

Full text not available from this repository.

Abstract

The subthalamic nucleus (STN) receives monosynaptic glutamatergic afferents from different areas of the cortex, known as the hyperdirect'' pathway. The STN has been divided into three distinct subdivisions, motor, limbic, and associative parts in line with the concept of parallel information processing. The extent to which the parallel information processing coming from distinct cortical areas overlaps in the different territories of the STN is still a matter of debate and the proposed role of dopaminergic neurons in maintaining the coherence of responses to cortical inputs in each territory is not documented. Using extracellular electrophysiological approaches, we investigated to what degree the motor and non-motor regions in the STN are segregated in control and dopamine (DA) depleted rats. We performed electrical stimulation of different cortical areas and recorded STN neuronal responses. We showed that motor and non-motor cortico-subthalamic pathways are not fully segregated, but partially integrated in the rat. This integration was mostly present through the indirect pathway. The spatial distribution and response latencies were the same in sham and 6-hydroxydopamine lesioned animals. The inhibitory phase was, however, less apparent in the lesioned animals. In conclusion, this study provides the first evidence that motor and non-motor cortico-subthalamic pathways in the rat are not fully segregated, but partially integrated. This integration was mostly present through the indirect pathway. We also show that the inhibitory phase induced by GABAergic inputs from the external segment of the globus pallidus is reduced in the DA-depleted animals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Janssen, Marcus L. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Temel, Yasin UNSPECIFIED UNSPECIFIED UNSPECIFIED Delaville, Claire UNSPECIFIED UNSPECIFIED UNSPECIFIED Zwartjes, Daphne G. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heida, Tjitske UNSPECIFIED UNSPECIFIED UNSPECIFIED De Deurwaerdere, Philippe UNSPECIFIED orcid.org/0000-0002-1226-3516 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Benazzouz, Abdelhamid UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-223220
DOI:	10.1007/s00429-016-1351-5
Journal or Publication Title:	Brain Struct. Funct.
Volume:	222
Number:	6
Page Range:	S. 2473 - 2486
Date:	2017
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-2661
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-FREQUENCY STIMULATION; ADVANCED PARKINSON-DISEASE; DEEP BRAIN-STIMULATION; BASAL GANGLIA; GLOBUS-PALLIDUS; NUCLEUS STIMULATION; FUNCTIONAL-ANATOMY; PREFRONTAL CORTEX; FOLLOW-UP; ORGANIZATION Multiple languages Anatomy & Morphology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22322