Universität zu Köln

Maurer, Christian, Martel, Samuel, Zardavas, Dimitrios and Ignatiadis, Michail (2017). New agents for endocrine resistance in breast cancer. Breast, 34. S. 1 - 12. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1532-3080

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Abstract

Estrogen receptor positive (ER+) and HER2-negative (HER2-) breast cancer (BC) is the most common BC subtype, defined by expression of the ER and absence of HER2 amplification. Endocrine treatment (ET), aiming at therapeutic blockade of ER signaling, represents the therapeutic mainstay for patients with both early and advanced disease. Despite its wide therapeutic efficacy, ET fails for a proportion of ER+, HER2- BC patients with early disease who develop endocrine resistance, resulting in disease recurrence. Endocrine resistance occurs almost invariably in patients with metastatic disease. Recently, increasing understanding of the molecular mediators of endocrine resistance has been achieved. This review focuses on the molecular mechanisms mediating endocrine resistance, on molecularly targeted agents to overcome or delay it, and potential predictive biomarkers for accurate patient stratification. (C) 2017 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maurer, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Martel, Samuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Zardavas, Dimitrios UNSPECIFIED UNSPECIFIED UNSPECIFIED Ignatiadis, Michail UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-223638
DOI:	10.1016/j.breast.2017.04.007
Journal or Publication Title:	Breast
Volume:	34
Page Range:	S. 1 - 12
Date:	2017
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1532-3080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ESTROGEN-RECEPTOR-ALPHA; GROWTH-FACTOR RECEPTOR; EVEROLIMUS PLUS EXEMESTANE; KINASE 4/6 INHIBITOR; RANDOMIZED PHASE-II; CYCLIN D1; POSTMENOPAUSAL WOMEN; DOUBLE-BLIND; ESR1 MUTATIONS; PROGESTERONE-RECEPTOR Multiple languages Oncology; Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22363