Universität zu Köln

Duncker, David, Westenfeld, Ralf, Konrad, Torsten, Pfeffer, Tobias, de Freitas, Carlos A. Correia, Pfister, Roman, Thomas, Dierk, Fuernkranz, Alexander, Andrie, Rene P., Napp, Andreas, Schmitt, Joern, Karolyi, Laszlo, Wakili, Reza, Hilfiker-Kleiner, Denise, Bauersachs, Johann and Veltmann, Christian (2017). Risk for life-threatening arrhythmia in newly diagnosed peripartum cardiomyopathy with low ejection fraction: a German multi-centre analysis. Clin. Res. Cardiol., 106 (8). S. 582 - 590. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

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Abstract

Introduction Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy characterized by an acute reduction in left ventricular ejection fraction (LVEF). Sudden deaths during the course of PPCM are reported to be elevated, the underlying mechanisms remains unknown. The aim of the present multi-centre study was to evaluate the arrhythmia burden in a multi-centre approach in patients with PPCM using a wearable cardioverter/defibrillator (WCD). Methods and results Forty-nine patients from 16 German centres with newly diagnosed PPCM and LVEF <= 35% receiving a WCD were included in this retrospective analysis. Mean follow-up was 15 +/- 10 months. At diagnosis, mean age was 33 +/- 5 years, parity was 2.1 +/- 1.6, LVEF was 21 +/- 7%, NYHA functional class was 3.4 +/- 0.7. Mean wear time was 120 +/- 106 days, mean wear time per day was 21.4 +/- 3.3 h. Six (12%) patients presented eight ventricular tachyarrhythmias during WCD period: five episodes of VF, two sustained ventricular tachycardia (VT) and one non-sustained VT occurred. Conclusion This multicentre study underpins the elevated risk for ventricular tachyarrhythmias in patients with newly diagnosed PPCM and reduced LVEF. A WCD should be considered for 3-6 months in these patients to prevent sudden cardiac death from ventricular tachyarrhythmias.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Duncker, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Westenfeld, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeffer, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED de Freitas, Carlos A. Correia UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Dierk UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuernkranz, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Andrie, Rene P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Napp, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitt, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Karolyi, Laszlo UNSPECIFIED UNSPECIFIED UNSPECIFIED Wakili, Reza UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilfiker-Kleiner, Denise UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauersachs, Johann UNSPECIFIED UNSPECIFIED UNSPECIFIED Veltmann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-223678
DOI:	10.1007/s00392-017-1090-5
Journal or Publication Title:	Clin. Res. Cardiol.
Volume:	106
Number:	8
Page Range:	S. 582 - 590
Date:	2017
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1861-0692
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WEARABLE CARDIOVERTER-DEFIBRILLATOR; HEART-FAILURE ASSOCIATION; LEFT-VENTRICULAR FUNCTION; CARDIOLOGY WORKING GROUP; EUROPEAN-SOCIETY; MANAGEMENT; REGISTRY; WOMEN Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22367