Universität zu Köln

Heppt, Markus V., Roesch, Alexander, Weide, Benjamin, Gutzmer, Ralf, Meier, Friedegund, Loquai, Carmen, Kaehler, Katharina C., Gesierich, Anja, Meissner, Markus, von Bubnoff, Dagmar, Goeppner, Daniela, Schlaak, Max, Pfoehler, Claudia, Utikal, Jochen ORCID: 0000-0001-5316-0241, Heinzerling, Lucie, Cosgarea, Ioana, Engel, Jutta, Eckel, Renate, Martens, Alexander, Mirlach, Laura, Satzger, Imke, Schubert-Fritschle, Gabriele, Tietze, Julia K. and Berking, Carola (2017). Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma. Eur. J. Cancer, 81. S. 36 - 45. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

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Abstract

Background: Mucosal melanoma (MM) is a rare but diverse cancer entity. Prognostic factors are not well established for Caucasians with MM. Patients and methods: We analysed the disease course of 444 patients from 15 German skin cancer centres. Disease progression was determined with the cumulative incidence function. Survival times were estimated with the Kaplan-Meier method. Prognostic parameters were identified with multivariate Cox regression analysis. Results: Common anatomic sites of primary tumours were head and neck (MMHN, 37.2%), female genital tract (MMFG, 30.4%) and anorectal region (MMAN, 21.8%). MMAN patients showed the highest vertical tumour thickness (p = 0.001), had a more advanced nodal status (p = 0.014) and a higher percentage of metastatic disease (p = 0.001) at diagnosis. Mutations of NRAS (13.8%), KIT (8.6%) and BRAF (6.4%) were evenly distributed across all tumour site groups. Local relapses were observed in 32.4% and most commonly occurred in the MMHN group (pZ0.016). Male gender (p = 0.047), advanced tumour stage (p = 0.001), nodal disease (p = 0.001) and incomplete resection status (p = 0.001) were independent risk factors for disease progression. Overall survival (OS) was highest in the MMFG group (p = 0.030) and in patients without ulceration (p = 0.004). Multivariate risk factors for OS were M stage at diagnosis (p = 0.002) and incomplete resection of the primary tumour (p = 0.001). Conclusion: In this large series of MM patients in a European population, anorectal MM was associated with the poorest prognosis. (C) 2017 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heppt, Markus V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roesch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Weide, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutzmer, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Meier, Friedegund UNSPECIFIED UNSPECIFIED UNSPECIFIED Loquai, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaehler, Katharina C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gesierich, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Meissner, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bubnoff, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeppner, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaak, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfoehler, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Utikal, Jochen UNSPECIFIED orcid.org/0000-0001-5316-0241 UNSPECIFIED Heinzerling, Lucie UNSPECIFIED UNSPECIFIED UNSPECIFIED Cosgarea, Ioana UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckel, Renate UNSPECIFIED UNSPECIFIED UNSPECIFIED Martens, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Mirlach, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Satzger, Imke UNSPECIFIED UNSPECIFIED UNSPECIFIED Schubert-Fritschle, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Tietze, Julia K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berking, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-223970
DOI:	10.1016/j.ejca.2017.05.014
Journal or Publication Title:	Eur. J. Cancer
Volume:	81
Page Range:	S. 36 - 45
Date:	2017
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1879-0852
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RETROSPECTIVE ANALYSIS; MALIGNANT-MELANOMA; KIT EXPRESSION; CANCER CENTER; SINONASAL; HEAD; NECK; MUTATIONS; EFFICACY; IMATINIB Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22397