Ghadri, Jelena R., Cammann, Victoria L., Jurisic, Stjepan, Seifert, Burkhardt ORCID: 0000-0002-5829-2478, Napp, L. Christian ORCID: 0000-0001-9945-0842, Diekmann, Johanna, Bataiosu, Dana Roxana, D'Ascenzo, Fabrizio ORCID: 0000-0002-6646-9317, Ding, Katharina J., Sarcon, Annahita, Kazemian, Elycia, Birri, Tanja, Ruschitzka, Frank, Luscher, Thomas F., Templin, Christian, Jaguszewski, Milosz ORCID: 0000-0002-2555-593X, Franke, Jennifer, Katus, Hugo A., Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Tschoepe, Carsten, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Ukena, Christian, Boehm, Michael, Erbel, Raimund, Cuneo, Alessandro, Jacobshagen, Claudius, Hasenfuss, Gerd, Karakas, Mahir, Koenig, Wolfgang, Rottbauer, Wolfgang, Said, Samir M., Braun-Dullaeus, Ruediger C., Cuculi, Florim, Banning, Adrian ORCID: 0000-0002-2842-7861, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Fijalkowski, Marcin, Rynkiewicz, Andrzej ORCID: 0000-0002-5284-9511, Opolski, Grzegorz, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan ORCID: 0000-0002-9240-6731, Galiuto, Leonarda, Crea, Filippo, Dichtl, Wolfgang ORCID: 0000-0002-0421-2110, Franz, Wolfgang M., Empen, Klaus, Felix, Stephan B., Delmas, Clement ORCID: 0000-0001-9180-9128, Lairez, Olivier, Erne, Paul, Frantz, Stefan, Prasad, Abhiram and Bax, Jeroen J. (2017). A novel clinical score (InterTAK Diagnostic Score) to differentiate takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry. Eur. J. Heart Fail., 19 (8). S. 1036 - 1043. HOBOKEN: WILEY. ISSN 1879-0844

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Abstract

Aims Clinical presentation of takotsubo syndrome (TTS) mimics acute coronary syndrome (ACS) and does not allow differentiation. We aimed to develop a clinical score to estimate the probability of TTS and to distinguish TTS from ACS in the acute stage. Methods and results Patients with TTS were recruited from the International Takotsubo Registry (www.takotsubo-registry.com) and ACS patients from the leading hospital in Zurich. A multiple logistic regression for the presence of TTS was performed in a derivation cohort (TTS, n = 218; ACS, n = 436). The best model was selected and formed a score (InterTAK Diagnostic Score) with seven variables, and each was assigned a score value: female sex 25, emotional trigger 24, physical trigger 13, absence of ST-segment depression (except in lead aVR) 12, psychiatric disorders 11, neurologic disorders 9, and QTc prolongation 6 points. The area under the curve (AUC) for the resulting score was 0.971 [95% confidence interval (CI) 0.96-0.98] and using a cut-off value of 40 score points, sensitivity was 89% and specificity 91%. When patients with a score of >= 50 were diagnosed as TTS, nearly 95% of TTS patients were correctly diagnosed. When patients with a score <= 31 were diagnosed as ACS, similar to 95% of ACS patients were diagnosed correctly. The score was subsequently validated in an independent validation cohort (TTS, n = 173; ACS, n = 226), resulting in a score AUC of 0.901 (95% CI 0.87-0.93). Conclusion The InterTAK Diagnostic Score estimates the probability of the presence of TTS and is able to distinguish TTS from ACS with a high sensitivity and specificity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ghadri, Jelena R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cammann, Victoria L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jurisic, StjepanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, BurkhardtUNSPECIFIEDorcid.org/0000-0002-5829-2478UNSPECIFIED
Napp, L. ChristianUNSPECIFIEDorcid.org/0000-0001-9945-0842UNSPECIFIED
Diekmann, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bataiosu, Dana RoxanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Ascenzo, FabrizioUNSPECIFIEDorcid.org/0000-0002-6646-9317UNSPECIFIED
Ding, Katharina J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarcon, AnnahitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kazemian, ElyciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Birri, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruschitzka, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luscher, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Templin, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaguszewski, MiloszUNSPECIFIEDorcid.org/0000-0002-2555-593XUNSPECIFIED
Franke, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katus, Hugo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgdorf, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schunkert, HeribertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauersachs, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tschoepe, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajan, LawrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michels, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ukena, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehm, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erbel, RaimundUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuneo, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobshagen, ClaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasenfuss, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karakas, MahirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottbauer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Said, Samir M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun-Dullaeus, Ruediger C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuculi, FlorimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banning, AdrianUNSPECIFIEDorcid.org/0000-0002-2842-7861UNSPECIFIED
Fischer, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasankari, TuijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Airaksinen, K. E. JuhaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fijalkowski, MarcinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rynkiewicz, AndrzejUNSPECIFIEDorcid.org/0000-0002-5284-9511UNSPECIFIED
Opolski, GrzegorzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dworakowski, RafalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacCarthy, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osswald, StefanUNSPECIFIEDorcid.org/0000-0002-9240-6731UNSPECIFIED
Galiuto, LeonardaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crea, FilippoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dichtl, WolfgangUNSPECIFIEDorcid.org/0000-0002-0421-2110UNSPECIFIED
Franz, Wolfgang M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Empen, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felix, Stephan B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delmas, ClementUNSPECIFIEDorcid.org/0000-0001-9180-9128UNSPECIFIED
Lairez, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erne, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frantz, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, AbhiramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bax, Jeroen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-223989
DOI: 10.1002/ejhf.683
Journal or Publication Title: Eur. J. Heart Fail.
Volume: 19
Number: 8
Page Range: S. 1036 - 1043
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1879-0844
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STRESS CARDIOMYOPATHY; RISK SCORE; TAKO-TSUBO; FEATURES; OUTCOMES; PROFILEMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22398

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