Universität zu Köln

Hoeper, Marius M., Kramer, Tilmann, Pan, Zixuan, Eichstaedt, Christina A., Spiesshoefer, Jens ORCID: 0000-0001-8205-1749, Benjamin, Nicola, Olsson, Karen M., Meyer, Katrin, Vizza, Carmine Dario, Vonk-Noordegraaf, Anton, Distler, Oliver ORCID: 0000-0002-0546-8310, Opitz, Christian, Gibbs, J. Simon R., Delcroix, Marion, Ghofrani, H. Ardeschir, Huscher, Doerte, Pittrow, David, Rosenkranz, Stephan and Gruenig, Ekkehard (2017). Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model. Eur. Resp. J., 50 (2). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 1399-3003

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Abstract

The 2015 European pulmonary hypertension (PH) guidelines propose a risk stratification strategy for patients with pulmonary arterial hypertension (PAH). Low-, intermediate-and high-risk strata are defined by estimated 1-year mortality risks of <5%, 5-10% and > 10%, respectively. This risk assessment strategy awaits validation. We analysed data from patients with newly diagnosed PAH enrolled into COMPERA (Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension), a European-based PH registry. An abbreviated version of the risk assessment strategy proposed by the European PH guidelines was applied, using the following variables: World Health Organization functional class, 6-min walking distance, brain natriuretic peptide or its N-terminal fragment, right atrial pressure, cardiac index and mixed venous oxygen saturation. Data from 1588 patients were analysed. Mortality rates were significantly different between the three risk strata (p<0.001 for all comparisons). In the entire patient population, the observed mortality rates 1 year after diagnosis were 2.8% in the low-risk cohort (n=196), 9.9% in the intermediate-risk cohort (n=1116) and 21.2% in the high-risk cohort (n=276). In addition, the risk assessment strategy proved valid at follow-up and in major PAH subgroups. An abbreviated version of the risk assessment strategy proposed by the current European PH guidelines provides accurate mortality estimates in patients with PAH.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoeper, Marius M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kramer, Tilmann UNSPECIFIED UNSPECIFIED UNSPECIFIED Pan, Zixuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichstaedt, Christina A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spiesshoefer, Jens UNSPECIFIED orcid.org/0000-0001-8205-1749 UNSPECIFIED Benjamin, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Olsson, Karen M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Vizza, Carmine Dario UNSPECIFIED UNSPECIFIED UNSPECIFIED Vonk-Noordegraaf, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Distler, Oliver UNSPECIFIED orcid.org/0000-0002-0546-8310 UNSPECIFIED Opitz, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Gibbs, J. Simon R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Delcroix, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghofrani, H. Ardeschir UNSPECIFIED UNSPECIFIED UNSPECIFIED Huscher, Doerte UNSPECIFIED UNSPECIFIED UNSPECIFIED Pittrow, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenkranz, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruenig, Ekkehard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-224053
DOI:	10.1183/13993003.00740-2017
Journal or Publication Title:	Eur. Resp. J.
Volume:	50
Number:	2
Date:	2017
Publisher:	EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication:	SHEFFIELD
ISSN:	1399-3003
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMBINATION THERAPY; ASSESSMENTS; MANAGEMENT; REGISTRY Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22405