Bos, Isabelle, Vos, Stephanie J., Froelich, Lutz, Kornhuber, Johannes ORCID: 0000-0002-8096-3987, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Maier, Wolfgang, Peters, Oliver, Ruether, Eckhart, Engelborghs, Sebastiaan, Niemantsverdriet, Ellis ORCID: 0000-0002-5781-3817, De Roeck, Ellen Elisa, Tsolaki, Magda ORCID: 0000-0002-2072-8010, Freund-Levim, Yvonne, Johannsen, Peter ORCID: 0000-0002-0528-1070, Vandenberghe, Rik ORCID: 0000-0001-6237-2502, Lleo, Alberto, Alcolea, Daniel ORCID: 0000-0002-3819-3245, Frisoni, Giovanni B., Galluzzi, Samantha ORCID: 0000-0001-9804-5669, Nobili, Flavio ORCID: 0000-0001-9811-0897, Morbelli, Silvia ORCID: 0000-0002-7833-6095, Drzezga, Alexander, Didic, Mira, van Berckel, Bart N., Salmon, Eric ORCID: 0000-0003-2520-9241, Bastin, Christine ORCID: 0000-0002-4556-9490, Dauby, Solene, Santana, Isabel, Baldeiras, Ines ORCID: 0000-0002-8106-7308, de Mendonca, Alexandre ORCID: 0000-0002-0488-1453, Silva, Dina, Wallin, Anders, Nordlund, Arto, Coloma, Preciosa M., Wientzek, Angelika ORCID: 0000-0002-9068-3022, Alexander, Myriam, Novak, Gerald P., Gordon, Mark Forrest, Wallin, Asa K., Hampel, Harald, Soininen, Hilkka, Herukka, Sanna-Kaisa, Scheltens, Philip ORCID: 0000-0002-1046-6408, Verhey, Frans R. and Visser, Pieter Jelle ORCID: 0000-0001-8008-9727 (2017). The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. Neurobiol. Aging, 56. S. 33 - 41. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497

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Abstract

We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Coxregression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hyper-cholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD. (C) 2017 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bos, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vos, Stephanie J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Froelich, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDorcid.org/0000-0002-8096-3987UNSPECIFIED
Wiltfang, JensUNSPECIFIEDorcid.org/0000-0003-1492-5330UNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruether, EckhartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engelborghs, SebastiaanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niemantsverdriet, EllisUNSPECIFIEDorcid.org/0000-0002-5781-3817UNSPECIFIED
De Roeck, Ellen ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsolaki, MagdaUNSPECIFIEDorcid.org/0000-0002-2072-8010UNSPECIFIED
Freund-Levim, YvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johannsen, PeterUNSPECIFIEDorcid.org/0000-0002-0528-1070UNSPECIFIED
Vandenberghe, RikUNSPECIFIEDorcid.org/0000-0001-6237-2502UNSPECIFIED
Lleo, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alcolea, DanielUNSPECIFIEDorcid.org/0000-0002-3819-3245UNSPECIFIED
Frisoni, Giovanni B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galluzzi, SamanthaUNSPECIFIEDorcid.org/0000-0001-9804-5669UNSPECIFIED
Nobili, FlavioUNSPECIFIEDorcid.org/0000-0001-9811-0897UNSPECIFIED
Morbelli, SilviaUNSPECIFIEDorcid.org/0000-0002-7833-6095UNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Didic, MiraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Berckel, Bart N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmon, EricUNSPECIFIEDorcid.org/0000-0003-2520-9241UNSPECIFIED
Bastin, ChristineUNSPECIFIEDorcid.org/0000-0002-4556-9490UNSPECIFIED
Dauby, SoleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santana, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldeiras, InesUNSPECIFIEDorcid.org/0000-0002-8106-7308UNSPECIFIED
de Mendonca, AlexandreUNSPECIFIEDorcid.org/0000-0002-0488-1453UNSPECIFIED
Silva, DinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallin, AndersUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordlund, ArtoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coloma, Preciosa M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wientzek, AngelikaUNSPECIFIEDorcid.org/0000-0002-9068-3022UNSPECIFIED
Alexander, MyriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Novak, Gerald P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gordon, Mark ForrestUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallin, Asa K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampel, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soininen, HilkkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herukka, Sanna-KaisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheltens, PhilipUNSPECIFIEDorcid.org/0000-0002-1046-6408UNSPECIFIED
Verhey, Frans R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser, Pieter JelleUNSPECIFIEDorcid.org/0000-0001-8008-9727UNSPECIFIED
URN: urn:nbn:de:hbz:38-224417
DOI: 10.1016/j.neurobiolaging.2017.03.034
Journal or Publication Title: Neurobiol. Aging
Volume: 56
Page Range: S. 33 - 41
Date: 2017
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1558-1497
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID BIOMARKERS; VASCULAR RISK; ALCOHOL-CONSUMPTION; DECLINE; DIAGNOSIS; ASSOCIATION; PREVALENCE; GUIDELINES; PROGNOSISMultiple languages
Geriatrics & Gerontology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22441

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