Universität zu Köln

Hoeller, Konstantin, Fabeni, Lavinia, Herling, Marco, Holtick, Udo, Scheid, Christof, Knops, Elena, Luebke, Nadine, Kaiser, Rolf, Pfister, Herbert and Di Cristanziano, Veronica (2017). Dynamics of BKPyV reactivation and risk of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. Eur. J. Haematol., 99 (2). S. 133 - 141. HOBOKEN: WILEY. ISSN 1600-0609

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Abstract

ObjectivesAim of this retrospective study was to analyze the dynamics of BKPyV reactivation in allogeneic hematopoietic stem cell transplant recipients in order to identify patients with higher risk to develop BKPyV-associated hemorrhagic cystitis (BKPyV-associated HC). MethodsThe study included 58 allo-HSCT recipients from the University Hospital of Cologne detected BKPyV positive by real-time PCR between 2009 and 2015. For correlative analysis, the first detected BKPyV-DNA load in urine and in plasma as well as the onset and severity of HC following the first day of conditioning regimen was considered. Phylogenetic analysis of BKPyV isolates was performed. ResultsIn 25 of 58 patients, BKPyV-DNA was detected in urine only (group U), whereas 33 patients developed additional viremia (group P). A chronologic sequence viruria-viremia-HC was identified. Viral load of >10(6) copies/mL at first viruria and evidence of viremia after 45days from the start of conditioning represented risk factors for the onset of HC. Molecular characterization revealed a non-stereotypic distribution of viral subtypes across groups U and P. ConclusionsMonitoring of BKPyV-DNA by real-time PCR after initiation of conditioning, regularly performed in clinical practice, can be a crucial tool for the early identification of patients with higher risk of BKPyV-associated HC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoeller, Konstantin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fabeni, Lavinia UNSPECIFIED UNSPECIFIED UNSPECIFIED Herling, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtick, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Knops, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Luebke, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-224504
DOI:	10.1111/ejh.12895
Journal or Publication Title:	Eur. J. Haematol.
Volume:	99
Number:	2
Page Range:	S. 133 - 141
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0609
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BK VIRUS-INFECTION; POLYOMAVIRUS BK; NEPHROPATHY; RECIPIENTS; IDENTIFICATION; ASSOCIATION; PREVALENCE; VIREMIA; PLASMA; URINE Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22450