Schwager, Evelyn E., Sharma, Prashant P., Clarke, Thomas, Leite, Daniel J., Wierschin, Torsten, Pechmann, Matthias, Akiyama-Oda, Yasuko ORCID: 0000-0002-7984-5932, Esposito, Lauren, Bechsgaard, Jesper, Bilde, Trine, Buffry, Alexandra D., Chao, Hsu, Dinh, Huyen, Doddapaneni, HarshaVardhan, Dugan, Shannon, Eibner, Cornelius, Extavour, Cassandra G., Funch, Peter ORCID: 0000-0002-0184-1552, Garb, Jessica, Gonzalez, Luis B., Gonzalez, Vanessa L., Griffiths-Jones, Sam ORCID: 0000-0001-6043-807X, Han, Yi, Hayashi, Cheryl, Hilbrant, Maarten, Hughes, Daniel S. T., Janssen, Ralf, Lee, Sandra L., Maeso, Ignacio ORCID: 0000-0002-6440-8457, Murali, Shwetha C., Muzny, Donna M., da Fonseca, Rodrigo Nunes, Paese, Christian L. B., Qu, Jiaxin, Ronshaugen, Matthew ORCID: 0000-0001-5326-5924, Schomburg, Christoph, Schonauer, Anna, Stollewerk, Angelika, Torres-Oliva, Montserrat ORCID: 0000-0003-4082-2810, Turetzek, Natascha, Vanthournout, Bram, Werren, John H., Wolff, Carsten ORCID: 0000-0002-5926-7338, Worley, Kim C., Bucher, Gregor ORCID: 0000-0002-4615-6401, Gibbs, Richard A., Coddington, Jonathan, Oda, Hiroki, Stanke, Mario ORCID: 0000-0001-8696-0384, Ayoub, Nadia A., Prpic, Nikola-Michael, Flot, Jean-Francois, Posnien, Nico, Richards, Stephen ORCID: 0000-0001-8959-5466 and McGregor, Alistair P. (2017). The house spider genome reveals an ancient whole-genome duplication during arachnid evolution. BMC Biol., 15. LONDON: BMC. ISSN 1741-7007

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Abstract

Background: The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum. Results: We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication. Conclusions: Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schwager, Evelyn E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sharma, Prashant P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clarke, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leite, Daniel J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wierschin, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pechmann, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akiyama-Oda, YasukoUNSPECIFIEDorcid.org/0000-0002-7984-5932UNSPECIFIED
Esposito, LaurenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechsgaard, JesperUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilde, TrineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buffry, Alexandra D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chao, HsuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dinh, HuyenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doddapaneni, HarshaVardhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dugan, ShannonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eibner, CorneliusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Extavour, Cassandra G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Funch, PeterUNSPECIFIEDorcid.org/0000-0002-0184-1552UNSPECIFIED
Garb, JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez, Luis B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez, Vanessa L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Griffiths-Jones, SamUNSPECIFIEDorcid.org/0000-0001-6043-807XUNSPECIFIED
Han, YiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayashi, CherylUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilbrant, MaartenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hughes, Daniel S. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janssen, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Sandra L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maeso, IgnacioUNSPECIFIEDorcid.org/0000-0002-6440-8457UNSPECIFIED
Murali, Shwetha C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muzny, Donna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
da Fonseca, Rodrigo NunesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paese, Christian L. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Qu, JiaxinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ronshaugen, MatthewUNSPECIFIEDorcid.org/0000-0001-5326-5924UNSPECIFIED
Schomburg, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schonauer, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stollewerk, AngelikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Torres-Oliva, MontserratUNSPECIFIEDorcid.org/0000-0003-4082-2810UNSPECIFIED
Turetzek, NataschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanthournout, BramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werren, John H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolff, CarstenUNSPECIFIEDorcid.org/0000-0002-5926-7338UNSPECIFIED
Worley, Kim C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bucher, GregorUNSPECIFIEDorcid.org/0000-0002-4615-6401UNSPECIFIED
Gibbs, Richard A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coddington, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oda, HirokiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stanke, MarioUNSPECIFIEDorcid.org/0000-0001-8696-0384UNSPECIFIED
Ayoub, Nadia A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prpic, Nikola-MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flot, Jean-FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Posnien, NicoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richards, StephenUNSPECIFIEDorcid.org/0000-0001-8959-5466UNSPECIFIED
McGregor, Alistair P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-224586
DOI: 10.1186/s12915-017-0399-x
Journal or Publication Title: BMC Biol.
Volume: 15
Date: 2017
Publisher: BMC
Place of Publication: LONDON
ISSN: 1741-7007
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Zoologisches Institut
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MESOBUTHUS-MARTENSII REVEALS; HOX GENES; EXPRESSION PATTERNS; DOSAGE-SENSITIVITY; SEQUENCE ALIGNMENT; CUPIENNIUS-SALEI; HOMEOBOX GENES; SCALE; CONSEQUENCES; PRESERVATIONMultiple languages
BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22458

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