Universität zu Köln

Koerner, Christian, Simoneau, Camille R., Schommers, Philipp ORCID: 0000-0003-3375-6800, Granoff, Mitchell, Ziegler, Maja, Hoelzemer, Angelique, Lunemann, Sebastian, Chukwukelu, Janet, Corleis, Bjorn, Naranbhai, Vivek, Kwon, Douglas S., Scully, Eileen P., Jost, Stephanie, Kirchhoff, Frank ORCID: 0000-0002-7052-2360, Carrington, Mary and Altfeld, Marcus ORCID: 0000-0001-5972-2997 (2017). HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. Cell Host Microbe, 22 (1). S. 111 - 124. CAMBRIDGE: CELL PRESS. ISSN 1934-6069

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Abstract

It was widely accepted that HIV-1 downregulates HLA-A/B to avoid CTL recognition while leaving HLA-C unaltered in order to prevent NK cell activation by engaging inhibitory NK cell receptors, but it was recently observed that most primary isolates of HIV-1 can mediate HLA-C downmodulation. Now we report that HIV-1-mediated downmodulation of HLA-C was associated with reduced binding to its respective inhibitory receptors. Despite this, HLA-C-licensed NK cells displayed reduced antiviral activity compared to their unlicensed counterparts, potentially due to residual binding to the respective inhibitory receptors. Nevertheless, NK cells were able to sense alterations of HLA-C expression demonstrated by increased antiviral activity when exposed to viral strains with differential abilities to downmodulate HLA-C. These results suggest that the capability of HLA-C-licensed NK cells to control HIV-1 replication is determined by the strength of KIR/HLA-C interactions and is thus dependent on both host genetics and the extent of virus-mediated HLA-C downregulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koerner, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Simoneau, Camille R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schommers, Philipp UNSPECIFIED orcid.org/0000-0003-3375-6800 UNSPECIFIED Granoff, Mitchell UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziegler, Maja UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelzemer, Angelique UNSPECIFIED UNSPECIFIED UNSPECIFIED Lunemann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Chukwukelu, Janet UNSPECIFIED UNSPECIFIED UNSPECIFIED Corleis, Bjorn UNSPECIFIED UNSPECIFIED UNSPECIFIED Naranbhai, Vivek UNSPECIFIED UNSPECIFIED UNSPECIFIED Kwon, Douglas S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scully, Eileen P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jost, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhoff, Frank UNSPECIFIED orcid.org/0000-0002-7052-2360 UNSPECIFIED Carrington, Mary UNSPECIFIED UNSPECIFIED UNSPECIFIED Altfeld, Marcus UNSPECIFIED orcid.org/0000-0001-5972-2997 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-225010
DOI:	10.1016/j.chom.2017.06.008
Journal or Publication Title:	Cell Host Microbe
Volume:	22
Number:	1
Page Range:	S. 111 - 124
Date:	2017
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1934-6069
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NATURAL-KILLER-CELLS; VIRUS; REPLICATION; EXPRESSION; KIR3DL1; INFECTION; FREQUENCY; CAPACITY; BINDING; LYSIS Multiple languages Microbiology; Parasitology; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22501