Universität zu Köln

Grau, Stefan J., Hampl, Juergen A., Kohl, Ann-Cathrin, Timmer, Marco, Duval, Inga V., Blau, Tobias, Ruge, Maximilian I. and Goldbrunner, Roland H. (2017). Impact of Resection on Survival of Isocitrate Dehydrogenase 1-Mutated World Health Organization Grade II Astrocytoma After Malignant Progression. World Neurosurg., 103. S. 180 - 186. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-8769

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Abstract

OBJECTIVE: To evaluate the impact of surgical resection and adjuvant treatment on the course of patients after malignant progression of previously treated isocitrate dehydrogenase 1 (IDH1)-mutated World Health Organization (WHO) grade II astrocytoma. METHODS: This retrospective study explored 56 patients undergoing tumor resection for malignant progression after previously treated IDH1-mutated WHO grade II astrocytoma. We analyzed survival after malignant progression, analyzed overall survival (OS), and identified prognostic factors using Kaplan-Meier estimates and log-rank test. RESULTS: By the time of malignant transformation, median age was 44 years, and median Karnofsky Performance Status (KPS) score was 90. Complete resection of contrastenhancing tissue was achieved in 18 (32.1%) patients. Median survival after re-resection was 33 months (95% confidence interval [CI], 20-46); median OS was 123 months (95% CI, 77-170). Gross total tumor resection, postoperative KPS score >= 80, adjuvant radiochemotherapy, and prior radiotherapy significantly correlated with postmalignant progression survival. CONCLUSIONS: Patients in good clinical condition with malignant progression of previously treated low-grade gliomas should receive aggressive treatment, including re-resection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grau, Stefan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hampl, Juergen A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohl, Ann-Cathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmer, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Duval, Inga V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruge, Maximilian I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-225772
DOI:	10.1016/j.wneu.2017.03.123
Journal or Publication Title:	World Neurosurg.
Volume:	103
Page Range:	S. 180 - 186
Date:	2017
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-8769
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL-PRACTICE GUIDELINE; ANAPLASTIC ASTROCYTOMA; GLIOMAS; TEMOZOLOMIDE; GLIOBLASTOMA; RADIOTHERAPY; MANAGEMENT; RECURRENCE; RADIATION; OUTCOMES Multiple languages Clinical Neurology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22577