Universität zu Köln

Tzschoppe, Anja, von Kries, Ruediger, Struwe, Ellen, Rascher, Wolfgang, Doerr, Helmuth-Guenther, Juengert, Joerg, Rauh, Manfred, Beckmann, Matthias, Schild, Ralf, Goecke, Tamme W. and Doetsch, Joerg (2017). Intrauterine Growth Restriction (IUGR) Induces Signs of Subclinical Atherosclerosis in 6-Year-Old Infants Despite Absence Of Excessive Growth. Klinische Padiatr., 229 (4). S. 209 - 216. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3824

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Abstract

Background Postnatal catch-up growth and rapid weight gain after intrauterine growth restriction (IUGR) seem to increase the risk for later disease. This study aimed to compare features of the metabolic syndrome early in life between IUGR and appropriate for gestational age (AGA) infants. Patients Data for 9 infants with IUGR defined by a birth weight<10 (th) percentile and ultrasound-proven placental insufficiency and 11 AGA children were available. Method Postnatal growth, auxological, cardiovascular, and metabolic parameters up to a chronological age of 6 years were assessed: Fasting serum concentrations of LDL-cholesterol, insulin, leptin, IGF-I, DHEAS, skinfold thicknesses, blood pressure, and mean carotid intima-media thickness (cIMT). Results All IUGR infants showed catch-up growth, although mean BMI SDS and total subcutaneous fat mass at the age of 6 years were still slightly lower compared to the AGA cohort. Reduced serum leptin concentrations were observed in IUGR infants (p=0.02), whereas no significant difference was found for IGF-I, insulin, LDL-cholesterol and DHEAS concentrations. Mean cIMT was significantly higher in IUGR infants (p<0.05). Mean arterial pressure did no differ. Discussion and Conclusion In 6-year-old IUGR infants with catch-up growth, who still had a slightly reduced BMI SDS compared to the AGA group, signs of subclinical atherosclerosis were detectable suggesting that cardiovascular risk in IUGR may be present even in the absence of excessive growth.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tzschoppe, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED von Kries, Ruediger UNSPECIFIED UNSPECIFIED UNSPECIFIED Struwe, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Rascher, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Doerr, Helmuth-Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Juengert, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Rauh, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Beckmann, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schild, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Goecke, Tamme W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-225788
DOI:	10.1055/s-0043-104528
Journal or Publication Title:	Klinische Padiatr.
Volume:	229
Number:	4
Page Range:	S. 209 - 216
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3824
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOR-GESTATIONAL-AGE; CATCH-UP GROWTH; BLOOD-PRESSURE; PROTEIN RESTRICTION; METABOLIC SYNDROME; BIRTH-WEIGHT; FETAL-GROWTH; CHILDREN; LIFE; HYPERTENSION Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22578