Universität zu Köln

Lopez-Pastorini, Alberto, Riedel, Richard, Koryllos, Aris, Beckers, Frank, Ludwig, Corinna and Stoelben, Erich (2017). The impact of preoperative elevated serum C-reactive protein on postoperative morbidity and mortality after anatomic resection for lung cancer. Lung Cancer, 109. S. 68 - 74. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-8332

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Abstract

Introduction: The aim of this study was to determine whether preoperative elevated serum C-reactive protein (CRP) is an independent risk factor of postoperative morbidity and mortality after pulmonary resection for lung cancer. Material and methods: A retrospective analysis of prospectively collected data on 1414 consecutive patients that underwent an anatomic resection for lung cancer was performed. Patients' characteristics, operative procedures and the postoperative outcome were assessed with a standardised data entry form. Univariate and multivariate analyses were conducted to identify factors that affect morbidity and mortality. Results: Postoperative complications occurred in 35.5% of the patients. The mortality rate was 3.2%. Patients with preoperative C-reactive protein above 40 mg/1 showed more overall complications and a higher mortality than patients below this limit. Patients with a CRP level between 3 mg/1 and 40 mg/I had no significant increase in morbidity and mortality compared to patients with values below the detection limit (< 3 mg/1). Conclusions: Preoperative serum C-reactive protein level is an independent and significant indicator for elevated morbidity and mortality after pulmonary resection. We propose the evaluation of CRP levels as a preoperative diagnostic modality of risk assessment in addition to standardised functional testing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lopez-Pastorini, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Koryllos, Aris UNSPECIFIED UNSPECIFIED UNSPECIFIED Beckers, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Ludwig, Corinna UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoelben, Erich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-225921
DOI:	10.1016/j.lungcan.2017.05.003
Journal or Publication Title:	Lung Cancer
Volume:	109
Page Range:	S. 68 - 74
Date:	2017
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-8332
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYSTEMIC INFLAMMATION; NUTRITIONAL-STATUS; CELL CARCINOMA; LEVEL; ASSOCIATION; POPULATION; SURVIVAL; SURGERY; MARKER; CRP Multiple languages Oncology; Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22592