Tahmasian, Masoud ORCID: 0000-0003-3999-3807, Eickhoff, Simon B. ORCID: 0000-0001-6363-2759, Giehl, Kathrin, Schwartz, Frank, Herz, Damian M., Drzezga, Alexander, van Eimeren, Thilo, Laird, Angela R., Fox, Peter T., Khazaie, Habibolah ORCID: 0000-0002-8066-9753, Zarei, Mojtaba, Eggers, Carsten and Eickhoff, Claudia R. (2017). Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis. Cortex, 92. S. 119 - 139. PARIS: ELSEVIER MASSON, CORP OFF. ISSN 1973-8102

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Abstract

Parkinson's disease (PD) is a common progressive neurodegenerative disorder. Studies using resting-state functional magnetic resonance imaging (fMRI) to investigate underlying pathophysiology of motor and non-motor symptoms in PD yielded largely inconsistent results. This quantitative neuroimaging meta-analysis aims to identify consistent abnormal intrinsic functional patterns in PD across studies. We used PubMed to retrieve suitable resting-state studies and stereotactic data were extracted from 28 individual between-group comparisons. Convergence across their findings was tested using the activation likelihood estimation (ALE) approach. We found convergent evidence for intrinsic functional disturbances in bilateral inferior parietal lobule (IPL) and the supramarginal gyrus in PD patients compared to healthy subjects. In follow-up task-based and task-independent functional connectivity (FC) analyses using two independent healthy subject data sets, we found that the regions showing convergent aberrations in PD formed an interconnected network mainly with the default mode network (DMN). Behavioral characterization of these regions using the BrainMap database suggested associated dysfunction of perception and executive processes. Taken together, our findings highlight the role of parietal cortex in the pathophysiology of PD. (C) 2017 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Tahmasian, MasoudUNSPECIFIEDorcid.org/0000-0003-3999-3807UNSPECIFIED
Eickhoff, Simon B.UNSPECIFIEDorcid.org/0000-0001-6363-2759UNSPECIFIED
Giehl, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwartz, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herz, Damian M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Eimeren, ThiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laird, Angela R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fox, Peter T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khazaie, HabibolahUNSPECIFIEDorcid.org/0000-0002-8066-9753UNSPECIFIED
Zarei, MojtabaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eggers, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eickhoff, Claudia R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-226536
DOI: 10.1016/j.cortex.2017.03.016
Journal or Publication Title: Cortex
Volume: 92
Page Range: S. 119 - 139
Date: 2017
Publisher: ELSEVIER MASSON, CORP OFF
Place of Publication: PARIS
ISSN: 1973-8102
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEFAULT-MODE NETWORK; CORTICO-STRIATAL CONNECTIVITY; SPONTANEOUS BRAIN ACTIVITY; OBSTRUCTIVE SLEEP-APNEA; DRUG-NAIVE PATIENTS; REGIONAL HOMOGENEITY; BASAL GANGLIA; SENSORIMOTOR INTEGRATION; COACTIVATION PATTERNS; NEURAL CONNECTIVITYMultiple languages
Behavioral Sciences; Neurosciences; Psychology, ExperimentalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22653

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