Universität zu Köln

Tillmar, Andreas O., Kling, Daniel, Butler, John M., Parson, Walther ORCID: 0000-0002-5692-2392, Prinz, Mechthild, Schneider, Peter M. ORCID: 0000-0003-0744-2349, Egeland, Thore and Gusmao, Leonor ORCID: 0000-0003-0432-6481 (2017). DNA Commission of the International Society for Forensic Genetics ( ISFG): Guidelines on the use of X-STRs in kinship analysis. Forensic Sci. Int.-Genet., 29. S. 269 - 276. CLARE: ELSEVIER IRELAND LTD. ISSN 1878-0326

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Abstract

Forensic genetic laboratories perform an increasing amount of genetic analyses of the X chromosome, in particular to solve complex cases of kinship analysis. For some biological relationships X-chromosomal markers can be more informative than autosomal markers, and there are a large number of markers, methods and databases that have been described for forensic use. Due to their particular mode of inheritance, and their physical location on a single chromosome, some specific considerations are required when estimating the weight of evidence for X-chromosomal marker DNA data. The DNA Commission of the International Society for Forensic Genetics (ISFG) hereby presents guidelines and recommendations for the use of X-chromosomal markers in kinship analysis with a special focus on the biostatistical evaluation. Linkage and linkage disequilibrium (association of alleles) are of special importance for such evaluations and these concepts and the implications for likelihood calculations are described in more detail. Furthermore it is important to use appropriate computer software that accounts for linkage and linkage disequilibrium among loci, as well as for mutations. Even though some software exist, there is still a need for further improvement of dedicated software. (C) 2017 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tillmar, Andreas O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kling, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Butler, John M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Parson, Walther UNSPECIFIED orcid.org/0000-0002-5692-2392 UNSPECIFIED Prinz, Mechthild UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Peter M. UNSPECIFIED orcid.org/0000-0003-0744-2349 UNSPECIFIED Egeland, Thore UNSPECIFIED UNSPECIFIED UNSPECIFIED Gusmao, Leonor UNSPECIFIED orcid.org/0000-0003-0432-6481 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-226595
DOI:	10.1016/j.fsigen.2017.05.005
Journal or Publication Title:	Forensic Sci. Int.-Genet.
Volume:	29
Page Range:	S. 269 - 276
Date:	2017
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1878-0326
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHROMOSOMAL MARKERS; GENERAL-MODEL; LIKELIHOOD COMPUTATIONS; LINKAGE DISEQUILIBRIUM; POPULATION-GENETICS; LINKED MARKERS; LOCI; RECOMMENDATIONS; MULTIPLEX; PATERNITY Multiple languages Genetics & Heredity; Medicine, Legal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22659