Treutlein, Jens, Frank, Josef, Streit, Fabian, Reinbold, Celine S., Juraeva, Dilafruz, Degenhardt, Franziska, Rietschel, Liz, Witt, Stephanie H., Forstner, Andreas J., Ridinger, Monika, Strohmaier, Jana ORCID: 0000-0002-4364-1487, Wodarz, Norbert, Dukal, Helene, Foo, Jerome C., Hoffmann, Per ORCID: 0000-0002-6573-983X, Herms, Stefan ORCID: 0000-0002-2786-8200, Heilmann-Heimbach, Stefanie ORCID: 0000-0003-1057-465X, Soyka, Michael, Maier, Wolfgang, Gaebel, Wolfgang, Dahmen, Norbert, Scherbaum, Norbert, Mueller-Myhsok, Bertram, Lucae, Susanne, Ising, Marcus, Stickel, Felix, Berg, Thomas, Roggenbuck, Ulla, Joeckel, Karl-Heinz, Scholz, Henrike, Zimmermann, Ulrich S., Buch, Stephan, Sommer, Wolfgang H. ORCID: 0000-0002-5903-6521, Spanagel, Rainer, Brors, Benedikt ORCID: 0000-0001-5940-3101, Cichon, Sven, Mann, Karl, Kiefer, Falk, Hampe, Jochen ORCID: 0000-0002-2421-6127, Rosendahl, Jonas, Noethen, Markus M. and Rietschel, Marcella (2017). Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. Genes, 8 (7). BASEL: MDPI AG. ISSN 2073-4425

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Abstract

The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach (p(uncorrected) = 1.2 x 10(-6); p(corrected) = 0.020). This was driven by the AD subsample. No association with ADH1B was found in the combined ACP + ALC sample. On first inspection, this seems surprising, since ADH1B is a robustly replicated risk gene for AD and may therefore be expected to be associated also with subgroups of AD patients. The negative finding in the ACP + ALC sample, however, may reflect genetic stratification as well as random fluctuation of allele frequencies in the cases and controls, demonstrating the importance of large samples in which the phenotype is well assessed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Treutlein, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frank, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Streit, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinbold, Celine S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juraeva, DilafruzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Degenhardt, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rietschel, LizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, Stephanie H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forstner, Andreas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ridinger, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strohmaier, JanaUNSPECIFIEDorcid.org/0000-0002-4364-1487UNSPECIFIED
Wodarz, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dukal, HeleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foo, Jerome C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, PerUNSPECIFIEDorcid.org/0000-0002-6573-983XUNSPECIFIED
Herms, StefanUNSPECIFIEDorcid.org/0000-0002-2786-8200UNSPECIFIED
Heilmann-Heimbach, StefanieUNSPECIFIEDorcid.org/0000-0003-1057-465XUNSPECIFIED
Soyka, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaebel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dahmen, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherbaum, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Myhsok, BertramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lucae, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ising, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stickel, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roggenbuck, UllaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joeckel, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scholz, HenrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zimmermann, Ulrich S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buch, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sommer, Wolfgang H.UNSPECIFIEDorcid.org/0000-0002-5903-6521UNSPECIFIED
Spanagel, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brors, BenediktUNSPECIFIEDorcid.org/0000-0001-5940-3101UNSPECIFIED
Cichon, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mann, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiefer, FalkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampe, JochenUNSPECIFIEDorcid.org/0000-0002-2421-6127UNSPECIFIED
Rosendahl, JonasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noethen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rietschel, MarcellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-226606
DOI: 10.3390/genes8070183
Journal or Publication Title: Genes
Volume: 8
Number: 7
Date: 2017
Publisher: MDPI AG
Place of Publication: BASEL
ISSN: 2073-4425
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; ALDEHYDE DEHYDROGENASE; EUROPEAN-AMERICANS; MAXIMUM NUMBER; LIVER-DISEASE; ADH1C GENE; RISK LOCI; POLYMORPHISMS; METAANALYSIS; METABOLISMMultiple languages
Genetics & HeredityMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22660

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