Universität zu Köln

Whitwell, Jennifer L., Hoelinger, Guenter U., Antonini, Angelo ORCID: 0000-0003-1040-2807, Bordelon, Yvette, Boxer, Adam L., Colosimo, Carlo ORCID: 0000-0002-2216-3973, van Eimeren, Thilo, Golbe, Lawrence I., Kassubek, Jan ORCID: 0000-0002-7106-9270, Kurz, Carolin, Litvan, Irene ORCID: 0000-0002-3485-3445, Pantelyat, Alexander, Rabinovici, Gil, Respondek, Gesine, Rominger, Axel, Rowe, James B., Stamelou, Maria and Josephs, Keith A. (2017). Radiological Biomarkers for Diagnosis in PSP: Where Are We and Where Do We Need to Be? Mov. Disord., 32 (7). S. 955 - 972. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

PSP is a pathologically defined neurodegenerative tauopathy with a variety of clinical presentations including typical Richardson's syndrome and other variant PSP syndromes. A large body of neuroimaging research has been conducted over the past two decades, with many studies proposing different structural MRI and molecular PET/SPECT biomarkers for PSP. These include measures of brainstem, cortical and striatal atrophy, diffusion weighted and diffusion tensor imaging abnormalities, [18F] fluorodeoxyglucose PET hypometabolism, reductions in striatal dopamine imaging and, most recently, PET imaging with ligands that bind to tau. Our aim was to critically evaluate the degree to which structural and molecular neuroimaging metrics fulfill criteria for diagnostic biomarkers of PSP. We queried the PubMed, Cochrane, Medline, and PSYCInfo databases for original research articles published in English over the past 20 years using postmortem diagnosis or the NINDS-SPSP criteria as the diagnostic standard from 1996 to 2016. We define a five-level theoretical construct for the utility of neuroimaging biomarkers in PSP, with level 1 representing group-level findings, level 2 representing biomarkers with demonstrable individual-level diagnostic utility, level 3 representing biomarkers for early disease, level 4 representing surrogate biomarkers of PSP pathology, and level 5 representing definitive PSP biomarkers of PSP pathology. We discuss the degree to which each of the currently available biomarkers fit into this theoretical construct, consider the role of biomarkers in the diagnosis of Richardson's syndrome, variant PSP syndromes and autopsy confirmed PSP, and emphasize current shortfalls in the field. (C) 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Whitwell, Jennifer L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelinger, Guenter U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonini, Angelo UNSPECIFIED orcid.org/0000-0003-1040-2807 UNSPECIFIED Bordelon, Yvette UNSPECIFIED UNSPECIFIED UNSPECIFIED Boxer, Adam L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Colosimo, Carlo UNSPECIFIED orcid.org/0000-0002-2216-3973 UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Golbe, Lawrence I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, Jan UNSPECIFIED orcid.org/0000-0002-7106-9270 UNSPECIFIED Kurz, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Litvan, Irene UNSPECIFIED orcid.org/0000-0002-3485-3445 UNSPECIFIED Pantelyat, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Rabinovici, Gil UNSPECIFIED UNSPECIFIED UNSPECIFIED Respondek, Gesine UNSPECIFIED UNSPECIFIED UNSPECIFIED Rominger, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Rowe, James B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stamelou, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Josephs, Keith A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-226764
DOI:	10.1002/mds.27038
Journal or Publication Title:	Mov. Disord.
Volume:	32
Number:	7
Page Range:	S. 955 - 972
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROGRESSIVE SUPRANUCLEAR PALSY; POSITRON-EMISSION-TOMOGRAPHY; MULTIPLE-SYSTEM ATROPHY; VOXEL-BASED MORPHOMETRY; MAGNETIC-RESONANCE PARKINSONISM; APPARENT DIFFUSION-COEFFICIENT; RICHARDSON-OLSZEWSKI-SYNDROME; SUPERIOR CEREBELLAR PEDUNCLE; CEREBRAL GLUCOSE-METABOLISM; DOPAMINE TRANSPORTER LOSS Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22676