Universität zu Köln

Goltz, Diane, Gevensleben, Heidrun, Dietrich, Joern, Schroeck, Friederike, de Vos, Luka, Droege, Freya, Kristiansen, Glen, Schroeck, Andreas, Landsberg, Jennifer ORCID: 0000-0001-8029-3883, Bootz, Friedrich and Dietrich, Dimo (2017). PDCD1 (PD-1) promoter methylation predicts outcome in head and neck squamous cell carcinoma patients. Oncotarget, 8 (25). S. 41011 - 41021. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

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Abstract

Background: Biomarkers that facilitate the prediction of disease recurrence in head and neck squamous cell carcinoma (HNSCC) may enable physicians to personalize treatment. In the current study, DNA promoter methylation of programmed cell death 1 (PDCD1, PD-1) was evaluated as a prognostic biomarker in HNSCC patients. Results: High PDCD1 methylation (mPDCD1) was associated with a significantly shorter overall survival after surgical resection in both the discovery (HR = 2.24 [95% CI: 1.08-4.64], p = 0.029) and the validation cohort (HR = 1.54 [95% CI: 1.08-2.21], p = 0.017). In multivariate Cox proportional hazards analysis, PDCD1 methylation remained a significant prognostic factor for HNSCC (HR = 2.14 [95% CI: 1.19-3.84], p = 0.011). Further, mPDCD1 was strongly associated with the human papilloma virus (HPV) status. Materials and Methods: mPDCD1 was assessed retrospectively in a discovery cohort of 120 HNSCC patients treated at the University Hospital of Bonn and a validation cohort of 527 HNSCC cases analyzed by The Cancer Genome Atlas Research Network. Conclusions: PDCD1 methylation might aid the identification of HNSCC patients potentially benefitting from a radical or alternative treatment, particularly in the context of immunotherapies targeting PD-1/PD-L1.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goltz, Diane UNSPECIFIED UNSPECIFIED UNSPECIFIED Gevensleben, Heidrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietrich, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeck, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED de Vos, Luka UNSPECIFIED UNSPECIFIED UNSPECIFIED Droege, Freya UNSPECIFIED UNSPECIFIED UNSPECIFIED Kristiansen, Glen UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeck, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Landsberg, Jennifer UNSPECIFIED orcid.org/0000-0001-8029-3883 UNSPECIFIED Bootz, Friedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietrich, Dimo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-227568
DOI:	10.18632/oncotarget.17354
Journal or Publication Title:	Oncotarget
Volume:	8
Number:	25
Page Range:	S. 41011 - 41021
Date:	2017
Publisher:	IMPACT JOURNALS LLC
Place of Publication:	ORCHARD PARK
ISSN:	1949-2553
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HPV-ASSOCIATED HEAD; HUMAN-PAPILLOMAVIRUS; DNA METHYLATION; RADICAL PROSTATECTOMY; PROGNOSTIC BIOMARKER; CANCER-IMMUNOTHERAPY; OROPHARYNGEAL CANCER; T-CELLS; SURVIVAL; BLOCKADE Multiple languages Oncology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22756