Universität zu Köln

Eming, Sabine A., Wynn, Thomas A. and Martin, Paul ORCID: 0000-0002-2665-5086 (2017). Inflammation and metabolism in tissue repair and regeneration. Science, 356 (6342). S. 1026 - 1031. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

Tissue repair after injury is a complex, metabolically demanding process. Depending on the tissue's regenerative capacity and the quality of the inflammatory response, the outcome is generally imperfect, with some degree of fibrosis, which is defined by aberrant accumulation of collagenous connective tissue. Inflammatory cells multitask at the wound site by facilitating wound debridement and producing chemokines, metabolites, and growth factors. If this well-orchestrated response becomes dysregulated, the wound can become chronic or progressively fibrotic, with both outcomes impairing tissue function, which can ultimately lead to organ failure and death. Here we review the current understanding of the role of inflammation and cell metabolism in tissue-regenerative responses, highlight emerging concepts that may expand therapeutic perspectives, and briefly discuss where important knowledge gaps remain.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eming, Sabine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wynn, Thomas A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Paul UNSPECIFIED orcid.org/0000-0002-2665-5086 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-227881
DOI:	10.1126/science.aam7928
Journal or Publication Title:	Science
Volume:	356
Number:	6342
Page Range:	S. 1026 - 1031
Date:	2017
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	1095-9203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MACROPHAGE POLARIZATION; SUCCINATE-DEHYDROGENASE; MEDIATED INFLAMMATION; PULMONARY-FIBROSIS; MECHANISMS; CELLS; ZEBRAFISH; DISTINCT; DISEASE; HEART Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22788