Universität zu Köln

Karlstetter, Marcus, Dannhausen, Katharina and Langmann, Thomas (2017). Microglia and immunomodulatory therapies for retinal degenerative diseases. Med. Genet., 29 (2). S. 225 - 234. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-5490

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Abstract

A chronic activation of the congenital immune system that is detrimental to the course of the disease underlies all forms of hereditary retinal degeneration investigated in detail so far. Above all, resident microglial cells of the retina and various proteins of the soluble complement system contribute to damage to photoreceptors and the retinal pigment epithelium. Specific target structures on reactive immune cells in addition to dysregulated soluble immune regulators offer a new starting point for treatments to promote the survival of the retina, despite a genetic predisposition to degeneration. In this article, we provide an insight into the essential regulatory mechanisms of retinal immunology, discuss the potential use of immunological biomarkers for diagnosing retinal conditions, and demonstrate immunomodulatory therapies through the use of biological agents and endogenous messengers.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Karlstetter, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Dannhausen, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-228324
DOI:	10.1007/s11825-017-0132-8
Journal or Publication Title:	Med. Genet.
Volume:	29
Number:	2
Page Range:	S. 225 - 234
Date:	2017
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-5490
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PHOTORECEPTOR CELL-DEATH; 18 KDA TSPO; RETINITIS-PIGMENTOSA; MACULAR DEGENERATION; COMPLEMENT ACTIVATION; A2E ACCUMULATION; GENE-EXPRESSION; MINOCYCLINE; PROTECTS; MOUSE Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22832