Universität zu Köln

Hong, Jiaxu, Yang, Yujing, Cursiefen, Claus, Mashaghi, Alireza ORCID: 0000-0002-2157-1211, Wu, Dan, Liu, Zuguo, Sun, Xinghuai, Dana, Reza and Xu, Jianjiang (2017). Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography. Br. J. Ophthalmol., 101 (6). S. 820 - 828. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2079

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Abstract

Purpose To present in vivo anterior segment optical coherence tomography (OCT) features of infants with Peters' anomaly obtained during presurgical examination under general anaesthesia, and to evaluate the impact of OCT features on surgical decision making. Methods This is a single-centre, consecutive, observational case series including 44 eyes of 27 infants with Peters' anomaly (5-18 months) undergoing keratoplasty. Medical records of patients were reviewed retrospectively. Clinical features and OCT findings, along with their impact on surgical decision-making were analysed. Results Of 27 patients, 10 had unilateral and 17 had bilateral disease. Two patients with mild disease (three eyes) had a posterior corneal defect with leukoma (2/27, 7.4%). Twenty patients (32 eyes) with iridocorneal adhesions were classified as having moderate Peters' anomaly (20/27, 74.1%) and five patients (nine eyes) with lenticulocorneal adhesions were classified as having severe Peters' anomaly (5/27, 18.5%). The range of angle closure, anterior chamber depth and maximum iridocorneal adhesion length (all p<0.001) were significantly different among groups, indicating that they might serve as novel OCT parameters for assessing the severity of Peters' anomaly. The surgical approach in seven patients (21.2%) was altered in response to intraoperative OCT findings, which provided information regarding the anatomical structure of the anterior chamber not provided by the surgical microscope. The use of OCT prevented unnecessary cataract surgeries in five patients. Conclusions Our study showed that information gained from OCT under anaesthesia allows surgeons to classify type and severity of Peters' anomaly and supports surgical decision making.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hong, Jiaxu UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Yujing UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Mashaghi, Alireza UNSPECIFIED orcid.org/0000-0002-2157-1211 UNSPECIFIED Wu, Dan UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Zuguo UNSPECIFIED UNSPECIFIED UNSPECIFIED Sun, Xinghuai UNSPECIFIED UNSPECIFIED UNSPECIFIED Dana, Reza UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Jianjiang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-229113
DOI:	10.1136/bjophthalmol-2016-308658
Journal or Publication Title:	Br. J. Ophthalmol.
Volume:	101
Number:	6
Page Range:	S. 820 - 828
Date:	2017
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-2079
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONGENITAL CORNEAL OPACITIES; PENETRATING KERATOPLASTY; LAMELLAR KERATOPLASTY; GLAUCOMA; CHILDREN; MALFORMATIONS; BIOMICROSCOPY; MANAGEMENT; SURGERY; DSAEK Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22911