Universität zu Köln

Mengotti, Paola ORCID: 0000-0001-8427-1737, Dombert, Pascasie L., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Vossel, Simone ORCID: 0000-0002-6351-8849 (2017). Disruption of the Right Temporoparietal Junction Impairs Probabilistic Belief Updating. J. Neurosci., 37 (22). S. 5419 - 5429. WASHINGTON: SOC NEUROSCIENCE. ISSN 0270-6474

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Abstract

Generating and updating probabilistic models of the environment is a fundamental modus operandi of the human brain. Although crucial for various cognitive functions, the neural mechanisms of these inference processes remain to be elucidated. Here, we show the causal involvement of the right temporoparietal junction (rTPJ) in updating probabilistic beliefs and we provide new insights into the chronometry of the process by combining online transcranial magnetic stimulation (TMS) with computational modeling of behavioral responses. Female and male participants performed a modified location-cueing paradigm, where false information about the percentage of cue validity (% CV) was provided in half of the experimental blocks to prompt updating of prior expectations. Online double-pulse TMS over rTPJ 300 ms (but not 50 ms) after target appearance selectively decreased participants' updating of false prior beliefs concerning % CV, reflected in a decreased learning rate of a Rescorla-Wagner model. Online TMS over rTPJ also impacted on participants' explicit beliefs, causing them to overestimate % CV. These results confirm the involvement of rTPJ in updating of probabilistic beliefs, thereby advancing our understanding of this area's function during cognitive processing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mengotti, Paola UNSPECIFIED orcid.org/0000-0001-8427-1737 UNSPECIFIED Dombert, Pascasie L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Vossel, Simone UNSPECIFIED orcid.org/0000-0002-6351-8849 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-230619
DOI:	10.1523/JNEUROSCI.3683-16.2017
Journal or Publication Title:	J. Neurosci.
Volume:	37
Number:	22
Page Range:	S. 5419 - 5429
Date:	2017
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	0270-6474
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TEMPORO-PARIETAL JUNCTION; BAYESIAN MODEL SELECTION; SACCADIC EYE-MOVEMENTS; SPATIAL ATTENTION; HUMAN BRAIN; INFERENCE; BODY; MIND Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23061