Universität zu Köln

Schepers, Inga M. ORCID: 0000-0001-9460-8604, Beck, Anne-Kathrin, Braueer, Susann, Schwabe, Kerstin, Abdallat, Mahmoud, Sandmann, Pascale, Dengler, Reinhard, Rieger, Jochem W. and Krauss, Joachim K. (2017). Human centromedian-parafascicular complex signals sensory cues for goal-oriented behavior selection. Neuroimage, 152. S. 390 - 400. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

Full text not available from this repository.

Abstract

Experimental research has shown that the centromedian-parafascicular complex (CM-Pf) of the intralaminar thalamus is activated in attentional orienting and processing of behaviorally relevant stimuli. These observations resulted in the hypothesis that the CM-Pf plays a pivotal role in goal-oriented behavior selection. We here set out to test this hypothesis with electrophysiological recordings from patients with electrodes implanted in CM-Pf for deep brain stimulation (DBS) treatment of chronic neuropathic pain. Six patients participated in (1) an auditory three-class oddball experiment, which required a button press to target tones, but not to standard and deviant tones and in (2) a multi-speaker experiment with a target word that required attention selection and a target image that required response selection. Subjects showed transient neural responses (8-15 Hz) to the target tone and the target word. Two subjects additionally showed transient neural responses (15-25 Hz) to the target image. All sensory target stimuli were related to an internal goal and required a behavior selection (attention selection, response selection). In group analyses, neural responses were greater to target tones than deviant and standard tones and to target words than other task-relevant words that did not require attention selection. The transient neural responses occurred after the target stimuli but prior to the overt behavioral response. Our results demonstrate that in human subjects the CM-Pf is involved in signaling sensory inputs related to goal-oriented selection of behavior.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schepers, Inga M. UNSPECIFIED orcid.org/0000-0001-9460-8604 UNSPECIFIED Beck, Anne-Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Braueer, Susann UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwabe, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Abdallat, Mahmoud UNSPECIFIED UNSPECIFIED UNSPECIFIED Sandmann, Pascale UNSPECIFIED UNSPECIFIED UNSPECIFIED Dengler, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieger, Jochem W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krauss, Joachim K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-231113
DOI:	10.1016/j.neuroimage.2017.03.019
Journal or Publication Title:	Neuroimage
Volume:	152
Page Range:	S. 390 - 400
Date:	2017
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THALAMIC INTRALAMINAR NUCLEI; DEEP BRAIN-STIMULATION; CM-PF COMPLEX; PARKINSONS-DISEASE; SUPERIOR COLLICULUS; BASAL GANGLIA; CHOLINERGIC INTERNEURONS; THALAMOSTRIATAL PROJECTION; INFORMATION-TRANSMISSION; SQUIRREL-MONKEY Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23111