Universität zu Köln

Moonen, Anja J. H., Weiss, Peter H. ORCID: 0000-0002-5230-9080, Wiesing, Michael ORCID: 0000-0001-8287-127X, Weidner, Ralph ORCID: 0000-0002-4502-0166, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Reijnders, Jennifer S. A. M., Weber, Wim M. and Leentjens, Albert F. G. (2017). An fMRI study into emotional processing in Parkinson's disease: Does increased medial prefrontal activation compensate for striatal dysfunction? PLoS One, 12 (5). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Background Apart from a progressive decline of motor functions, Parkinson's disease (PD) is also characterized by non-motor symptoms, including disturbed processing of emotions. This study aims at assessing emotional processing and its neurobiological correlates in PD with the focus on how medicated Parkinson patients may achieve normal emotional responsiveness despite basal ganglia dysfunction. Methods Nineteen medicated patients with mild to moderate PD (without dementia or depression) and 19 matched healthy controls passively viewed positive, negative, and neutral pictures in an event-related blood oxygen level-dependent functional magnetic resonance imaging study (BOLD-fMRI). Individual subjective ratings of valence and arousal levels for these pictures were obtained right after the scanning. Results Parkinson patients showed similar valence and arousal ratings as controls, denoting intact emotional processing at the behavioral level. Yet, Parkinson patients showed decreased bilateral putaminal activation and increased activation in the right dorsomedial prefrontal cortex (PFC), compared to controls, both most pronounced for highly arousing emotional stimuli. Conclusions Our findings revealed for the first time a possible compensatory neural mechanism in Parkinson patients during emotional processing. The increased medial PFC activity may have modulated emotional responsiveness in patients via top-down cognitive control, therewith restoring emotional processing at the behavioral level, despite striatal dysfunction. These results may impact upon current treatment strategies of affective disorders in PD as patients may benefit from this intact or even compensatory influence of prefrontal areas when therapeutic strategies are applied that rely on cognitive control to modulate disturbed processing of emotions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moonen, Anja J. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED Wiesing, Michael UNSPECIFIED orcid.org/0000-0001-8287-127X UNSPECIFIED Weidner, Ralph UNSPECIFIED orcid.org/0000-0002-4502-0166 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Reijnders, Jennifer S. A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Wim M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leentjens, Albert F. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-231285
DOI:	10.1371/journal.pone.0177085
Journal or Publication Title:	PLoS One
Volume:	12
Number:	5
Date:	2017
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; DIAGNOSTIC-CRITERIA; LIMBIC SYSTEM; RATING-SCALE; DEPRESSION; AMYGDALA; RECOGNITION; AROUSAL; CORTEX; APATHY Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23128