Universität zu Köln

Ruud, Johan, Steculorum, Sophie M. and Bruening, Jens C. (2017). Neuronal control of peripheral insulin sensitivity and glucose metabolism. Nat. Commun., 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

The central nervous system (CNS) has an important role in the regulation of peripheral insulin sensitivity and glucose homeostasis. Research in this dynamically developing field has progressed rapidly due to techniques allowing targeted transgenesis and neurocircuitry mapping, which have defined the primary responsive neurons, associated molecular mechanisms and downstream neurocircuitries and processes involved. Here we review the brain regions, neurons and molecular mechanisms by which the CNS controls peripheral glucose metabolism, particularly via regulation of liver, brown adipose tissue and pancreatic function, and highlight the potential implications of these regulatory pathways in type 2 diabetes and obesity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ruud, Johan UNSPECIFIED UNSPECIFIED UNSPECIFIED Steculorum, Sophie M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-231359
DOI:	10.1038/ncomms15259
Journal or Publication Title:	Nat. Commun.
Volume:	8
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BROWN ADIPOSE-TISSUE; K-ATP CHANNELS; DIET-INDUCED OBESITY; BODY-MASS INDEX; AGRP-NEURONS; LEPTIN RESISTANCE; FEEDING-BEHAVIOR; POMC NEURONS; FOOD-INTAKE; PROOPIOMELANOCORTIN NEURONS Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23135