Universität zu Köln

Schaefer, Maximilian S., Piper, Thomas ORCID: 0000-0002-7462-6693, Geyer, Hans, Schneemann, Julia, Neukirchen, Martin, Thevis, Mario and Kienbaum, Peter (2017). Xenon elimination kinetics following brief exposure. Drug Test. Anal., 9 (5). S. 666 - 671. HOBOKEN: WILEY. ISSN 1942-7611

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Abstract

Xenon is a modern inhalative anaesthetic with a very low solubility in tissues providing rapid elimination and weaning from anaesthesia. Besides its anaesthetic properties, Xenon promotes the endogenous erythropoietin biosynthesis and thus has been enlisted as prohibited substance by the World Anti-Doping Agency (WADA). For effective doping controls, knowledge about the elimination kinetics of Xenon and the duration of traceability are of particular importance. Seventy-seven full blood samples were obtained from 7 normal weight patients undergoing routine Xenon-based general anaesthesia with a targeted inspiratory concentration of 60% Xenon in oxygen. Samples were taken before and during Xenon inhalation as well as one, two, 4, 8, 16, 24, 32, 40, and 48 h after exposure. Xenon concentrations were assessed in full blood by gas chromatography and triple quadrupole tandemmass spectrometry with a detection limit of 0.25 mu mol/L. The elimination of Xenon was characterized by linear regression of log-transformed Xenon blood concentrations, as well as non-linear regression. Xenon exposure yielded maximum concentrations in arterial blood of 1.3 [1.1; 1.6] mmol/L.Xenon was traceable for 24 to 48h. The elimination profile was characterized by a biphasic pattern with a rapid alpha phase, followed by a slower beta phase showing a first order kinetics (c[Xe]= 69.1e(-0.26x), R-2 = 0.83, t(1/ 2) = 2.7 h). Time in hours after exposure could be estimated by 50*in(1.39/c[Xe](0.077)). Xenon's elimination kinetics is biphasic with a delayed beta phase following a first order kinetics. Xenon can reliably be detected for at least 24h after brief exposure. Copyright (C) 2016 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schaefer, Maximilian S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Piper, Thomas UNSPECIFIED orcid.org/0000-0002-7462-6693 UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneemann, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Neukirchen, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Kienbaum, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-231755
DOI:	10.1002/dta.2001
Journal or Publication Title:	Drug Test. Anal.
Volume:	9
Number:	5
Page Range:	S. 666 - 671
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RANDOMIZED CONTROLLED-TRIAL; PARTITION-COEFFICIENT; BLOOD; ANESTHESIA; GAS; PHARMACOKINETICS; SEVOFLURANE; ISOFLURANE; EMERGENCE; SURGERY Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23175