Universität zu Köln

Langmann, Thomas and Fauser, Sascha (2017). Polysialic Acid for Immunomodulation in an Animal Model for Wet Age-Related Macular Degeneration (AMD). Klinische Monatsblat. Augenheilkunde, 234 (5). S. 657 - 662. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

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Abstract

Background Chronic activation of the innate immune system is a hallmark of retinal degenerative diseases, including age-related macular degeneration (AMD). Overt microglia and macrophage reactivity, as well as dysregulation of the alternative complement system, trigger and sustain retinal degeneration. It is now accepted that there exists a vicious cycle of mononuclear phagocyte reactivity, abnormal intrinsic complement activation, damage of Bruch's membrane, dysfunction of the retinal pigment epithelium, photoreceptor degeneration and choroidal neovascularization (CNV). Targeting the innate immune system may, therefore, be a complementary approach to anti-angiogenic therapy. This article presents data from polysialic acid treatment experiments in the laser-induced mouse model of wet AMD. Material and Methods The laser-CNV mouse model was used to simulate events of neovascular AMD. Polysialic acid was applied by intravitreal injection and microglia activity was assessed with Iba1 staining of retinal and RPE/choroidal flat mounts. Neovascular leakage was determined by fluorescein angiography. Results Intravitreal injection of polysialic acid reduced retinal and RPE/choroidal lesion-associated microglia activity in the laser-induced mouse model of AMD. Polysialic acid treatment also diminished vascular leakage at laser spots in this model. Conclusion Local retinal immunomodulation with polysialic acid presents a novel concept for treatment of inflammatory conditions related to neovascular AMD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232040
DOI:	10.1055/s-0043-105138
Journal or Publication Title:	Klinische Monatsblat. Augenheilkunde
Volume:	234
Number:	5
Page Range:	S. 657 - 662
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3999
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FACTOR-H POLYMORPHISM; COMPLEMENT ACTIVATION; RETINAL DEGENERATION; MICROGLIA; NEOVASCULARIZATION; RISK; MICE; NEUROTOXICITY; MACROPHAGES; PROTEINS Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23204