Universität zu Köln

Choy, Ernest, Aletaha, Daniel, Behrens, Frank, Finckh, Axel, Gomez-Reino, Juan, Gottenberg, Jacques-Eric, Schuch, Florian and Rubbert-Roth, Andrea (2017). Monotherapy with biologic disease-modifying anti-rheumatic drugs in rheumatoid arthritis. RHEUMATOLOGY, 56 (5). S. 689 - 698. OXFORD: OXFORD UNIV PRESS. ISSN 1462-0332

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Abstract

Current EULAR guidelines state that biologic DMARD (bDMARD) therapy should be administered in combination with MTX or other conventional synthetic (cs) DMARD in RA. Nonetheless, a third of patients for whom a bDMARD agent is prescribed take it in the absence of concurrent csDMARD therapy. While the reasons underlying the low uptake of bDMARD-csDMARD combination therapy in clinical practice have not been well delineated, they may include poor adherence, contraindication to csDMARD therapy and adverse effects, as well as csDMARD withdrawal following remission. The challenges surrounding bDMARD therapy and the benefit/risk ratio of biologic monotherapy when compared with combination with a csDMARD will be discussed. We will provide insights into these important issues, as well as reviewing the evidence base differentiating biologic agents and exploring therapeutic options for patients with rheumatoid arthritis for whom csDMARD therapy is contraindicated or discontinued.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Choy, Ernest UNSPECIFIED UNSPECIFIED UNSPECIFIED Aletaha, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Behrens, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Finckh, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Gomez-Reino, Juan UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottenberg, Jacques-Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuch, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Rubbert-Roth, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232153
DOI:	10.1093/rheumatology/kew271
Journal or Publication Title:	RHEUMATOLOGY
Volume:	56
Number:	5
Page Range:	S. 689 - 698
Date:	2017
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1462-0332
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NECROSIS-FACTOR INHIBITORS; DOUBLE-BLIND; TOCILIZUMAB MONOTHERAPY; CLINICAL-TRIAL; FACTOR-ALPHA; METHOTREXATE; THERAPY; MULTICENTER; COMBINATION; ADALIMUMAB Multiple languages Rheumatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23215