Universität zu Köln

Schick, T., Steinhauer, M., Aslanidis, A., Altay, L., Karlstetter, M., Langmann, T., Kirschfink, M. and Fauser, S. (2017). Local complement activation in aqueous humor in patients with age-related macular degeneration. Eye, 31 (5). S. 810 - 814. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5454

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Abstract

Purpose To investigate complement activation in aqueous humor and in plasma of patients with neovascular age-related macular degeneration (nAMD). Patients and methods Aqueous humor and EDTA-plasma of 31 nAMD patients and 30 age-matched controls was collected. The levels of the complement factor 3 (C3), the regulators factor H (FH), and factor I (FI), and of the complement activation products Ba, C3a, and the terminal complement complex (sC5b-9) were measured. Associations between complement levels and phenotype were determined using Mann-Whitney U-test. Results In plasma, no significant differences were found between the nAMD group and the control group. In aqueous humor, significantly increased levels of Ba (P= 0.002), and C3a (P= 0.002) indicate local complement activation in nAMD patients and a trend for a concomitant upregulation of the complement regulators FH (P= 0.02) and FI (P= 0.04). Conclusions Our findings provide strong evidence for a local complement dysregulation in nAMD patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schick, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinhauer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Aslanidis, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Altay, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karlstetter, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langmann, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirschfink, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232343
DOI:	10.1038/eye.2016.328
Journal or Publication Title:	Eye
Volume:	31
Number:	5
Page Range:	S. 810 - 814
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5454
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FACTOR-H POLYMORPHISM; RISK; VARIANT; DEFICIENCY; HYPOTHESIS; COMPONENTS; DRUSEN Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23234