Universität zu Köln

Gruell, Henning and Klein, Florian (2017). Progress in HIV-1 antibody research using humanized mice. Curr. Opin. HIV AIDS, 12 (3). S. 285 - 294. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1746-6318

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Abstract

Purpose of review Recent discoveries of highly potent broadly HIV-1 neutralizing antibodies provide new opportunities to successfully prevent, treat, and potentially cure HIV-1 infection. To test their activity in vivo, humanized mice have been shown to be a powerful model and were used to investigate antibody-mediated prevention and therapy approaches. In this review, we will summarize recent findings in humanized mice that have informed on the potential use of broadly neutralizing antibodies targeting HIV-1 in humans. Recent findings Humanized mouse models have been used to demonstrate the antiviral efficacy of HIV-1 neutralizing antibodies in vivo. It has been shown that a combination of antibodies can suppress viremia below the limit of detection and targets the HIV-1 reservoir. Moreover, passively administered antibodies and vectormediated antibody production protect humanized mice from HIV-1 infection. Finally, immunization studies in knock-in/transgenic mice carrying human antibody gene segments have informed on potential vaccination strategies to induce broad and potent HIV-1 neutralizing antibodies. Summary Humanized mouse models are of great value for HIV-1 research. They represent a highly versatile in vivo system to investigate novel approaches for HIV-1 prevention and therapy and expedite the critical translation from basic findings to clinical application.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gruell, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232743
DOI:	10.1097/COH.0000000000000368
Journal or Publication Title:	Curr. Opin. HIV AIDS
Volume:	12
Number:	3
Page Range:	S. 285 - 294
Date:	2017
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1746-6318
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BROADLY NEUTRALIZING ANTIBODIES; IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODY; HEMATOPOIETIC STEM-CELLS; PBL-SCID MICE; IG KNOCKIN MICE; IN-VIVO; MOUSE MODEL; ANTI-HIV-1 ANTIBODIES; B-CELLS Multiple languages Immunology; Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23274