Universität zu Köln

Syed, Adnan S., Sansone, Alfredo ORCID: 0000-0002-1197-7322, Hassenklover, Thomas ORCID: 0000-0002-9895-1263, Manzini, Ivan ORCID: 0000-0002-3575-9637 and Korsching, Sigrun I. ORCID: 0000-0002-5450-172X (2017). Coordinated shift of olfactory amino acid responses and V2R expression to an amphibian water nose during metamorphosis. Cell. Mol. Life Sci., 74 (9). S. 1711 - 1720. BASEL: SPRINGER BASEL AG. ISSN 1420-9071

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Abstract

All olfactory receptors identified in teleost fish are expressed in a single sensory surface, whereas mammalian olfactory receptor gene families segregate into different olfactory organs, chief among them the main olfactory epithelium expressing ORs and TAARs, and the vomeronasal organ expressing V1Rs and V2Rs. A transitional stage is embodied by amphibians, with their vomeronasal organ expressing more 'modern', later diverging V2Rs, whereas more 'ancient', earlier diverging V2Rs are expressed in the main olfactory epithelium. During metamorphosis, the main olfactory epithelium of Xenopus tadpoles transforms into an air-filled cavity (principal cavity, air nose), whereas a newly formed cavity (middle cavity) takes over the function of a water nose. We report here that larval expression of ancient V2Rs is gradually lost from the main olfactory epithelium as it transforms into the air nose. Concomitantly, ancient v2r gene expression begins to appear in the basal layers of the newly forming water nose. We observe the same transition for responses to amino acid odorants, consistent with the hypothesis that amino acid responses may be mediated by V2R receptors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Syed, Adnan S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sansone, Alfredo UNSPECIFIED orcid.org/0000-0002-1197-7322 UNSPECIFIED Hassenklover, Thomas UNSPECIFIED orcid.org/0000-0002-9895-1263 UNSPECIFIED Manzini, Ivan UNSPECIFIED orcid.org/0000-0002-3575-9637 UNSPECIFIED Korsching, Sigrun I. UNSPECIFIED orcid.org/0000-0002-5450-172X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232953
DOI:	10.1007/s00018-016-2437-1
Journal or Publication Title:	Cell. Mol. Life Sci.
Volume:	74
Number:	9
Page Range:	S. 1711 - 1720
Date:	2017
Publisher:	SPRINGER BASEL AG
Place of Publication:	BASEL
ISSN:	1420-9071
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LARVAL XENOPUS-LAEVIS; EPITHELIUM; RECEPTORS; MAIN Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23295