Universität zu Köln

Mischnik, A., Baumert, P., Hamprecht, A., Rohde, A. M., Peter, S., Feihl, S., Knobloch, J., Goelz, H., Kola, A., Obermann, B., Querbach, C., Willmann, M., Gebhardt, F., Tacconelli, E., Gastmeier, P., Seifert, H. and Kern, W. V. (2017). In vitro susceptibility to 19 agents other than beta-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. J. Antimicrob. Chemother., 72 (5). S. 1359 - 1364. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

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Abstract

Objectives: As part of the multicentre Antibiotic Therapy Optimisation Study, MIC values of 19 non-b-lactam agents were determined for third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species (3GCREB) isolates collected in German hospitals. Methods: A total of 328 E. coli, 35 Klebsiella spp. (1 Klebsiella oxytoca and 34 Klebsiella pneumoniae) and 16 Enterobacter spp. (1 Enterobacter aerogenes and 15 Enterobacter cloacae) isolates were submitted to broth microdilution antimicrobial susceptibility testing with the MICRONAUT system. MICs of fluoroquinolones (levofloxacin and moxifloxacin), aminoglycosides (gentamicin, tobramycin, amikacin, streptomycin, neomycin and paromomycin), tetracyclines (tetracycline, minocycline and tigecycline), macrolides (erythromycin, clarithromycin and azithromycin) and miscellaneous agents [trimethoprim/sulfamethoxazole, chloramphenicol, nitrofurantoin, colistin and fosfomycin intravenous (iv)] were determined and reviewed against 2016 EUCAST breakpoints. Results: The MIC of levofloxacin was >2 mg/L for 128 of 328 E. coli and 8 of 35 Klebsiella spp., but only 1 of 16 Enterobacter spp. Rates of resistance to trimethoprim/sulfamethoxazole were high (>70%), except for Enterobacter spp. Rates of resistance to colistin and fosfomycin iv were still low. About 20% of the tested isolates were resistant to chloramphenicol. Only 1 (of 328) E. coli isolate had an MIC of amikacin >16 mg/L and only 33 of 328 E. coli and 1 of 35 Klebsiella spp. had an MIC of tobramycin >4 mg/L, whereas average gentamicin MICs were in general more elevated. A tigecycline MIC.2 mg/L was only found for 1 of 16 Enterobacter spp., but in none of the E. coli or Klebsiella spp. isolates. Conclusions: Our study gives insight into previously unreported non-b-lactam MIC distributions of 3GCREB isolates.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mischnik, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumert, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamprecht, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rohde, A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Peter, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feihl, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knobloch, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goelz, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kola, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermann, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Querbach, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Willmann, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gebhardt, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tacconelli, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gastmeier, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kern, W. V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233296
DOI:	10.1093/jac/dkw577
Journal or Publication Title:	J. Antimicrob. Chemother.
Volume:	72
Number:	5
Page Range:	S. 1359 - 1364
Date:	2017
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2091
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLISTIN; NITROFURANTOIN; TIGECYCLINE; MINOCYCLINE; FOSFOMYCIN; SYSTEM Multiple languages Infectious Diseases; Microbiology; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23329