Universität zu Köln

Hamisch, Christina A., Blau, Tobias, Klinger, Katharina, Kickingereder, Philipp, Ruess, Daniel, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Berthold, Frank, Simon, Thorsten, Grau, Stefan and Ruge, Maximilian I. (2017). Feasibility, Risk Profile and Diagnostic Yield of Stereotactic Biopsy in Children and Young Adults with Brain Lesions. Klinische Padiatr., 229 (3). S. 133 - 142. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3824

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Abstract

Objective To evaluate the feasibility, safety, and diagnostic yield of stereotactic biopsy (SB) in children and adolescents with cerebral lesions. Methods We performed a systematic review of the literature and a retrospective analysis of all pediatric and adolescent patients who underwent SB for unclear brain lesions at our center. We collected patient and lesion-associated parameters, analysed the rate of procedural complications and diagnostic yield. Results Our institutional series consisted of 285 SBs in 269 children and young adults between 1989 and 2016 (median age, 9 (range 1-18) years). There was no procedure-related mortality. Permanent and transient morbidity was 0.7 % and 5.8 %, respectively. Lesions were located in brain lobes (26.3 %) and in midline structures (73.7 %). The diagnostic yield was 97.5 % and histology consisted low-grade gliomas (44.2 %), high-grade gliomas (15.1 %), non-glial tumors (22.8 %), and non-neoplastic disease (15.4 %). Morbidity was not associated with tumor location, age, histology or intraoperative position of the patient. In order to compare our findings with previous reports, we reviewed 25 studies with 1 109 children and young adults which had underwent SB. The diagnostic yield ranged between 83 % and 100 %. The reported morbidity and mortality rates range from 0-27 % and 0-3.3 %, respectively. Conclusions SB in this particular patient population is a safe and a high-yield diagnostic procedure and indicates therefore its importance in the light of personalized medicine with the development of individual molecular treatment strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hamisch, Christina A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Klinger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kickingereder, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruess, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Berthold, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Grau, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruge, Maximilian I. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233387
DOI:	10.1055/s-0043-101908
Journal or Publication Title:	Klinische Padiatr.
Volume:	229
Number:	3
Page Range:	S. 133 - 142
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3824
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTRINSIC PONTINE GLIOMAS; STEM TUMORS; INTRACRANIAL LESIONS; PEDIATRIC-PATIENTS; GRADE GLIOMAS; TRANSCEREBELLAR; EXPERIENCE; MANAGEMENT; CHILDHOOD; SURGERY Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23338