Universität zu Köln

Vollmer, Christian, Weber, Andreas P. M., Wallenfang, Martin, Hoffmann, Till, Mettler-Altmann, Tabea, Truse, Richard ORCID: 0000-0001-6650-5800, Bauer, Inge, Picker, Olaf and Mathes, Alexander M. (2017). Melatonin pretreatment improves gastric mucosal blood flow and maintains intestinal barrier function during hemorrhagic shock in dogs. Microcirculation, 24 (4). HOBOKEN: WILEY. ISSN 1549-8719

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Abstract

ObjectiveMelatonin improves hepatic perfusion after hemorrhagic shock and may reduce stress-induced gastric lesions. This study was designed to investigate whether pretreatment with melatonin may influence gastric mucosal microcirculatory perfusion (flow), oxygenation (HbO(2)), or intestinal barrier function during physiological and hemorrhagic conditions in dogs. MethodsIn a randomized crossover study, five anesthetized foxhounds received melatonin 100gkg(-1) or vehicle (ethanol 5%) intravenously in the absence or presence of hemorrhagic shock (60minutes, -20% blood volume). Systemic hemodynamic variables, gastric mucosal perfusion, and oxygenation were recorded continuously; intestinal barrier function was assessed intermittently via xylose absorption. ResultsDuring hemorrhagic shock, melatonin significantly attenuated the decrease in flow, compared with vehicle (-199 vs -43 +/- 10aU, P<.05), without influence on HbO(2). A significant increase in xylose absorption was detected during hemorrhage in vehicle-treated dogs, compared with sham-operated animals (13 +/- 2 vs 8 +/- 1 relative amounts, P<.05); this was absent in melatonin-treated animals (6 +/- 1 relative amounts). Melatonin did not influence macrocirculation. ConclusionsMelatonin improves regional blood flow suggesting improved oxygen delivery in gastric mucosa during hemorrhagic shock. This could provide a mechanism for the observed protection of intestinal barrier function in dogs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vollmer, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Andreas P. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wallenfang, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED Mettler-Altmann, Tabea UNSPECIFIED UNSPECIFIED UNSPECIFIED Truse, Richard UNSPECIFIED orcid.org/0000-0001-6650-5800 UNSPECIFIED Bauer, Inge UNSPECIFIED UNSPECIFIED UNSPECIFIED Picker, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathes, Alexander M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233394
DOI:	10.1111/micc.12345
Journal or Publication Title:	Microcirculation
Volume:	24
Number:	4
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1549-8719
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MICROVASCULAR OXYGEN-SATURATION; HEPATIC PERFUSION; LIVER-FUNCTION; MICROCIRCULATORY PERFUSION; BETA-HYDROXYBUTYRATE; PROPOFOL ANESTHESIA; ANESTHETIZED DOGS; SEPTIC SHOCK; PINEAL-GLAND; IN-VIVO Multiple languages Hematology; Peripheral Vascular Disease Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23339