Universität zu Köln

Redeker, Jana, Blaeser, Marcel, Neupert, Susanne and Predel, Reinhard (2017). Identification and distribution of products from novel tryptopyrokinin genes in the locust, Locusta migratoria. Biochem. Biophys. Res. Commun., 486 (1). S. 70 - 76. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2104

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Abstract

A recent analysis of the genome of Locusta migratoria indicated the presence of four novel insect neuropeptide genes encoding for multiple tryptopyrokinin peptides (tryptoPKs); hitherto only known from pyrokinin or capa genes. In our study, mature products of tryptoPK genes 1 and 2 were identified by mass spectrometry; precursor sequences assigned to the tryptoPIC genes 3 and 4 are likely partial sequences of a single precursor. The expression of tryptoPK genes 1 and 2 is restricted to two cells in the sub esophageal ganglion, exhibiting not only a unique neuropeptidome but also a very distinctive axonal projection. Comparative neuroendocrinology revealed that homologous cells in other insects also produce tryptoPKs but use other genes to generate this pattern. Since capa and pyrokinin genes are discussed as ancestors of the tryptoPK genes, we completed the hitherto only partially known precursor sequences of these genes by means of transcriptome analyses. The distribution of mature products of CAPA and pyrokinin precursors in the CNS is compared with that of tryptoPKs. In addition, a novel pyrokinin-like precursor is described. (C) 2017 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Redeker, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaeser, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Neupert, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Predel, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233725
DOI:	10.1016/j.bbrc.2017.02.135
Journal or Publication Title:	Biochem. Biophys. Res. Commun.
Volume:	486
Number:	1
Page Range:	S. 70 - 76
Date:	2017
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2104
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ABDOMINAL PERISYMPATHETIC ORGANS; PROTEIN-COUPLED RECEPTORS; SUBESOPHAGEAL GANGLION; NEUROENDOCRINE SYSTEM; NEUROPEPTIDES; INSECT; NEUROHORMONES; PEPTIDOMICS; MORPHOLOGY; EXPRESSION Multiple languages Biochemistry & Molecular Biology; Biophysics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23372