Universität zu Köln

Chereau, Fanny, Madec, Yoann ORCID: 0000-0002-6201-1261, Sabina, Caroline, Obel, Niels, Ruiz-Mateos, Ezequiel ORCID: 0000-0001-6747-7813, Chrysos, Georgios, Fidler, Sarah ORCID: 0000-0003-1676-7583, Lehmann, Clara, Zangerle, Robert, Wittkop, Linda ORCID: 0000-0003-2403-0960, Reiss, Peter, Hamouda, Osamah, Estrada Perez, Vicente, Leal, Manuel, Mocroft, Amanda, Garcia De Olalla, Patricia, Ammassari, Adriana ORCID: 0000-0002-0284-0340, Monforte, Antonella D'Arminio, Mussini, Cristina, Segura, Ferran, Castagna, Antonella, Cavassini, Matthias, Grabar, Sophie, Morlat, Philippe, De Wit, Stephane, Lambotte, Olivier and Meyer, Laurence (2017). Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers. PLoS One, 12 (4). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Objective HIV controllers (HICs) spontaneously maintain HIV viral replication at low level without antiretroviral therapy (ART), a small number of whom will eventually lose this ability to control HIV viremia. The objective was to identify factors associated with loss of virological control. Methods HICs were identified in COHERE on the basis of >= 5 consecutive viral loads (VL) <= 500 copies/mL over >= 1 year whilst ART-naive, with the last VL <= 500 copies/mL measured >= 5 years after HIV diagnosis. Loss of virological control was defined as 2 consecutive VL > 2000 copies/mL. Duration of HIV control was described using cumulative incidence method, considering loss of virological control, ART initiation and death during virological control as competing outcomes. Factors associated with loss of virological control were identified using Cox models. CD4 and CD8 dynamics were described using mixed-effect linear models. Results We identified 1067 HICs; 86 lost virological control, 293 initiated ART, and 13 died during virological control. Six years after confirmation of HIC status, the probability of losing virological control, initiating ART and dying were 13%, 37%, and 2%. Current lower CD4/CD8 ratio and a history of transient viral rebounds were associated with an increased risk of losing virological control. CD4 declined and CD8 increased before loss of virological control, and before viral rebounds. Discussion Expansion of CD8 and decline of CD4 during HIV control may result from repeated low-level viremia. Our findings suggest that in addition to superinfection, other mechanisms, such as low grade viral replication, can lead to loss of virological control in HICs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chereau, Fanny UNSPECIFIED UNSPECIFIED UNSPECIFIED Madec, Yoann UNSPECIFIED orcid.org/0000-0002-6201-1261 UNSPECIFIED Sabina, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Obel, Niels UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruiz-Mateos, Ezequiel UNSPECIFIED orcid.org/0000-0001-6747-7813 UNSPECIFIED Chrysos, Georgios UNSPECIFIED UNSPECIFIED UNSPECIFIED Fidler, Sarah UNSPECIFIED orcid.org/0000-0003-1676-7583 UNSPECIFIED Lehmann, Clara UNSPECIFIED UNSPECIFIED UNSPECIFIED Zangerle, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittkop, Linda UNSPECIFIED orcid.org/0000-0003-2403-0960 UNSPECIFIED Reiss, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamouda, Osamah UNSPECIFIED UNSPECIFIED UNSPECIFIED Estrada Perez, Vicente UNSPECIFIED UNSPECIFIED UNSPECIFIED Leal, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Mocroft, Amanda UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia De Olalla, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Ammassari, Adriana UNSPECIFIED orcid.org/0000-0002-0284-0340 UNSPECIFIED Monforte, Antonella D'Arminio UNSPECIFIED UNSPECIFIED UNSPECIFIED Mussini, Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Segura, Ferran UNSPECIFIED UNSPECIFIED UNSPECIFIED Castagna, Antonella UNSPECIFIED UNSPECIFIED UNSPECIFIED Cavassini, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Grabar, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Morlat, Philippe UNSPECIFIED UNSPECIFIED UNSPECIFIED De Wit, Stephane UNSPECIFIED UNSPECIFIED UNSPECIFIED Lambotte, Olivier UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Laurence UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-234122
DOI:	10.1371/journal.pone.0173893
Journal or Publication Title:	PLoS One
Volume:	12
Number:	4
Date:	2017
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIRETROVIRAL THERAPY; T-CELLS; INVERSE PROBABILITY; NATURAL-HISTORY; RNA LEVELS; INFECTION; PROGRESSION; REPLICATION; ACTIVATION; ABSENCE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23412