Universität zu Köln

Wittersheim, Maike, Heydt, Carina, Hoffmann, Fabian ORCID: 0000-0002-3199-9924 and Buettner, Reinhard (2017). KRAS mutation in papillary fibroelastoma: a true cardiac neoplasm? J. Pathol. Clin. Res., 3 (2). S. 100 - 105. HOBOKEN: WILEY. ISSN 2056-4538

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Abstract

Primary cardiac tumours are rare and mostly benign lesions. Recent publications report that cardiac papillary fibroelastomas are the most common benign primary heart tumour, outnumbering myxomas. However, there is no consensus about their aetiology. We investigated the molecular profile of these tumours using next generation sequencing in a cohort of 16 cases. Eleven of 14 (79%) analysable tumours showed mutations of the KRAS oncogene. Our results provide unambiguous evidence that a significant proportion of these lesions are genuine neoplastic tumours caused by an oncogenic driver mutation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wittersheim, Maike UNSPECIFIED UNSPECIFIED UNSPECIFIED Heydt, Carina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Fabian UNSPECIFIED orcid.org/0000-0002-3199-9924 UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-234348
DOI:	10.1002/cjp2.66
Journal or Publication Title:	J. Pathol. Clin. Res.
Volume:	3
Number:	2
Page Range:	S. 100 - 105
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2056-4538
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ECHOCARDIOGRAPHIC CHARACTERISTICS; DIAGNOSIS; TUMORS Multiple languages Pathology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23434