Universität zu Köln

Thangarajah, Fabinshy, Enninga, Insa, Malter, Wolfram, Hamacher, Stefanie ORCID: 0000-0003-2158-9101, Markiefka, Birgid, Richters, Lisa, Kraemer, Stefan, Mallmann, Peter and Kirn, Verena (2017). A Retrospective Analysis of Ki-67 Index and its Prognostic Significance in Over 800 Primary Breast Cancer Cases. Anticancer Res., 37 (4). S. 1957 - 1965. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7530

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Abstract

Background/Aim: The Ki-67 index is chiefly important for distinguishing between luminal A and luminal B human epidermal growth factor receptor 2 (HER2neu)negative breast cancer subtypes. However, its ability to predict response to chemotherapy is uncertain. Patients and Methods: Patients treated for primary breast cancer at the University Hospital of Cologne were identified. Immunohistochemistry for Ki-67 detection was performed according to standard protocols. Kaplan-Meier survival curves were calculated and compared using the log-rank test. Results: Patients with low Ki-67 index had a significantly better disease-free-survival (DFS) than patients with high Ki-67 index (hazard ratio=2.85; 95% confidence interval=1.45-5.59; p=0.002). A significant influence on DFS was demonstrated (hazard ratio(HR)=1.02; confidence interval(CI)=1.00-1.04; p=0.048) within the subgroup of hormone receptor-positive and HER2neu-negative patients, but not within the subgroup of those with luminal B/HER2neu-negative tumors (DFS: p=0.801; overall-survival: p=0.379). Conclusion: The Ki-67 index has a prognostic impact on DFS in patients with hormone receptor-positive and HER2neu-negative tumors. The strict cut-off value was not suitable for distinguishing between high-and low-risk patients and their response to adjuvant chemotherapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thangarajah, Fabinshy UNSPECIFIED UNSPECIFIED UNSPECIFIED Enninga, Insa UNSPECIFIED UNSPECIFIED UNSPECIFIED Malter, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, Stefanie UNSPECIFIED orcid.org/0000-0003-2158-9101 UNSPECIFIED Markiefka, Birgid UNSPECIFIED UNSPECIFIED UNSPECIFIED Richters, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Kraemer, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirn, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-234580
DOI:	10.21873/anticanres.11536
Journal or Publication Title:	Anticancer Res.
Volume:	37
Number:	4
Page Range:	S. 1957 - 1965
Date:	2017
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7530
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERNATIONAL KI67; SUBTYPES; ANTIGEN; MARKERS; RECOMMENDATIONS; EXPRESSION; CARCINOMA; ANTIBODY; THERAPY; COHORT Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23458