Universität zu Köln

Becker, Johannes, Barbe, Michael T., Hartinger, Mariam, Dembek, Till A., Pochmann, Jil, Wirths, Jochen, Allert, Niels, Mücke, Doris ORCID: 0000-0002-6217-3121, Hermes, Anne ORCID: 0000-0003-1111-0005, Meister, Ingo G., Visser-Vandewalle, Veerle, Grice, Martine ORCID: 0000-0003-4973-4059 and Timmermann, Lars (2017). The Effect of Uni- and Bilateral Thalamic Deep Brain Stimulation on Speech in Patients With Essential Tremor: Acoustics and Intelligibility. Neuromodulation, 20 (3). S. 223 - 233. HOBOKEN: WILEY. ISSN 1525-1403

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Abstract

BackgroundDeep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is performed to suppress medically-resistant essential tremor (ET). However, stimulation induced dysarthria (SID) is a common side effect, limiting the extent to which tremor can be suppressed. To date, the exact pathogenesis of SID in VIM-DBS treated ET patients is unknown. ObjectiveWe investigate the effect of inactivated, uni- and bilateral VIM-DBS on speech production in patients with ET. We employ acoustic measures, tempo, and intelligibility ratings and patient's self-estimated speech to quantify SID, with a focus on comparing bilateral to unilateral stimulation effects and the effect of electrode position on speech. MethodsSixteen German ET patients participated in this study. Each patient was acoustically recorded with DBS-off, unilateral-right-hemispheric-DBS-on, unilateral-left-hemispheric-DBS-on, and bilateral-DBS-on during an oral diadochokinesis task and a read German standard text. To capture the extent of speech impairment, we measured syllable duration and intensity ratio during the DDK task. Naive listeners rated speech tempo and speech intelligibility of the read text on a 5-point-scale. Patients had to rate their ability to speak. ResultsWe found an effect of bilateral compared to unilateral and inactivated stimulation on syllable durations and intensity ratio, as well as on external intelligibility ratings and patients' VAS scores. Additionally, VAS scores are associated with more laterally located active contacts. For speech ratings, we found an effect of syllable duration such that tempo and intelligibility was rated worse for speakers exhibiting greater syllable durations. ConclusionOur data confirms that SID is more pronounced under bilateral compared to unilateral stimulation. Laterally located electrodes are associated with more severe SID according to patient's self-ratings. We can confirm the relation between diadochokinetic rate and SID in that listener's tempo and intelligibility ratings can be predicted by measured syllable durations from DDK tasks.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Becker, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartinger, Mariam UNSPECIFIED UNSPECIFIED UNSPECIFIED Dembek, Till A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pochmann, Jil UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirths, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Allert, Niels UNSPECIFIED UNSPECIFIED UNSPECIFIED Mücke, Doris UNSPECIFIED orcid.org/0000-0002-6217-3121 UNSPECIFIED Hermes, Anne UNSPECIFIED orcid.org/0000-0003-1111-0005 UNSPECIFIED Meister, Ingo G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Grice, Martine UNSPECIFIED orcid.org/0000-0003-4973-4059 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-235178
DOI:	10.1111/ner.12546
Journal or Publication Title:	Neuromodulation
Volume:	20
Number:	3
Page Range:	S. 223 - 233
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1525-1403
Language:	English
Faculty:	Faculty of Arts and Humanities
Divisions:	Faculty of Arts and Humanities > Fächergruppe 1: Kunstgeschichte, Musikwissenschaft, Medienkultur und Theater, Linguistik, IDH > Institut für Linguistik > Phonetik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSTERIOR SUBTHALAMIC AREA; PARKINSONS-DISEASE; VENTRALIS INTERMEDIUS; ORAL DIADOCHOKINESIS; FOLLOW-UP; NUCLEUS; DYSARTHRIA; DISORDERS; MOVEMENT; ARTICULATION Multiple languages Medicine, Research & Experimental; Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23517