Universität zu Köln

Gerhardt, Felix, Dumitrescu, Daniel, Gaertner, Carina, Beccard, Ralf, Viethen, Thomas, Kramer, Tilmann, Baldus, Stephan, Hellmich, Martin, Schoenau, Eckhard and Rosenkranz, Stephan (2017). Oscillatory whole-body vibration improves exercise capacity and physical performance in pulmonary arterial hypertension: a randomised clinical study. Heart, 103 (8). S. 592 - 599. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-201X

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Abstract

Objective In patients with pulmonary arterial hypertension ( PAH), supportive therapies may be beneficial in addition to targeted medical treatment. Here, we evaluated the effectiveness and safety of oscillatory whole-body vibration (WBV) in patients on stable PAH therapy. Methods Twenty-two patients with PAH (mean PAP >= 25 mm Hg and pulmonary arterial wedge pressure (PAWP)<= 15 mm Hg) who were in world health organization (WHO)-Functional Class II or III and on stable PAH therapy for >= 3 months, were randomised to receive WBV (16 sessions of 1-hour duration within 4 weeks) or to a control group, that subsequently received WBV. Follow-up measures included the 6-min walking distance (6MWD), cardiopulmonary exercise testing (CPET), echocardiography, muscle-power, and health-related quality of life (HRQoL; SF-36 and LPH questionnaires). Results When compared to the control group, patients receiving WBV exhibited a significant improvement in the primary endpoint, the 6MWD (+ 35.4 +/- 10.9 vs -4.4 +/- 7.6 m), resulting in a net benefit of 39.7 +/- 7.8m (p= 0.004). WBV was also associated with substantial improvements in CPET variables, muscle power, and HRQoL. The combined analysis of all patients (n= 22) indicated significant net improvements versus baseline in the 6MWD (+ 38.6 m), peakVO2 (+ 65.7 mL/min), anaerobic threshold (+ 40.9 mL VO2/min), muscle power (+ 4.4%), and HRQoL (SF-36 + 9.7, LPH -11.5 points) (all p< 0.05). WBV was well tolerated in all patients, and no procedure-related severe adverse events (SAEs) occurred. Conclusions WBV substantially improves exercise capacity, physical performance, and HRQoL in patients with PAH who are on stable targeted therapy. This methodology may be utilised in structured training programmes, and may be feasible for continuous long-term physical exercise in these patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gerhardt, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Dumitrescu, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaertner, Carina UNSPECIFIED UNSPECIFIED UNSPECIFIED Beccard, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Viethen, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kramer, Tilmann UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenkranz, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-235563
DOI:	10.1136/heartjnl-2016-309852
Journal or Publication Title:	Heart
Volume:	103
Number:	8
Page Range:	S. 592 - 599
Date:	2017
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-201X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; NURSING-HOME RESIDENTS; INTERNATIONAL SOCIETY; LUNG TRANSPLANTATION; CONTROLLED-TRIAL; MUSCLE FUNCTION; FALL RISK; RECOMMENDATIONS; ASSOCIATION; BENEFITS Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23556