Universität zu Köln

Jansen, S., Jerowski, M., Ludwig, L., Fischer-Krall, E., Beutner, D. and Grosheva, M. (2017). Botulinumtoxin therapy in Frey's syndrome: a retrospective study of 440 treatments in 100 patients. Clin. Otolaryngol., 42 (2). S. 295 - 301. HOBOKEN: WILEY. ISSN 1749-4486

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Abstract

Objective: Frey's syndrome is characterised as sweating, redness and warmth of the parotideal area and is often treated with botulinum toxin A. The objective of this retrospective study was to prove whether the toxin dosage and time-to-treatment intervals change after repeated botulinum toxin injections. Study design/methods: The charts of patients, who were treated for Frey's syndrome during the last 16 years, were assessed. Three brands of botulinum toxin A were available for therapy. The Minor test was used to confirm the sweating before each treatment and to determine the toxin dosage. Constant amount of botulinum toxin was injected per cm 2 of the affected area. Patients consulted our department for the next treatment as soon as they felt disturbed by recurring sweating and when the sweating was objectively evident in the Minor test. Time intervals between treatments and injected toxin dosages were assessed. Results: In total, 100 patients received 440 treatments in 16 years. Repeated injections, median 4.0, were carried out in 70.5% of patients. Median time interval to the first injection was 2.8 years. Median time interval between treatments was 12.0 months and showed to be steady (ANOVA, P = .49, F = 1.01). Conclusion: Duration of effect of botulinum toxin on Frey's syndrome was long-lasting and stable with no significantly different time intervals between treatments. The extent of the sweating area did not vary significantly after repeated treatments and required a constant dose of botulinum toxin A.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jansen, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jerowski, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ludwig, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer-Krall, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beutner, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grosheva, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-235703
DOI:	10.1111/coa.12719
Journal or Publication Title:	Clin. Otolaryngol.
Volume:	42
Number:	2
Page Range:	S. 295 - 301
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1749-4486
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TOXIN; PAROTIDECTOMY; SURGERY Multiple languages Otorhinolaryngology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23570